Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, 411001, India.
Interdiscplinary School of Health Sciences, Savitribai Phule University, Pune, Maharashtra, 411007, India.
Pediatr Diabetes. 2020 Sep;21(6):987-994. doi: 10.1111/pedi.13063. Epub 2020 Jul 8.
Children with type 1 diabetes having dyslipidemia are at increased risk of developing premature atherosclerosis and cardiovascular disease. The present study aims to determine the prevalence of dyslipidemia and its predictors in poorly controlled Indian children with type 1 diabetes.
The cross-sectional study included 235 children and youth (3-18 years) with type 1 diabetes having disease duration of at least 1 year. Demographic data and laboratory findings were obtained from patients' records.
The prevalence of dyslipidemia in our study was 47.2% with abnormal low-density lipoprotein cholesterol being the most common lipid abnormality. Poor glycemic control and higher thyroid stimulating hormone values were important predictors of likelihood of dyslipidemia and hypertriglyceridemia. Despite a low percentage of overweight and obese children in our study, body fat percentage was a significant predictor of likelihood of high total cholesterol and abnormal high-density lipoprootein. Interestingly, 28 children under the age of 10 years were found to have dyslipidemia, which constitutes 11.9% of the total study group.
We found a high prevalence of dyslipidemia in children with type 1 diabetes including children under age of 10 years, which emphasize the need for early screening and regular monitoring of lipid profile in these children.
患有血脂异常的 1 型糖尿病儿童发生早发性动脉粥样硬化和心血管疾病的风险增加。本研究旨在确定血脂异常及其预测因素在控制不佳的印度 1 型糖尿病儿童中的流行情况。
这项横断面研究纳入了 235 名患有至少 1 年病程的 1 型糖尿病的儿童和青少年（3-18 岁）。从患者的病历中获得了人口统计学数据和实验室检查结果。
在我们的研究中，血脂异常的患病率为 47.2%，其中异常的低密度脂蛋白胆固醇是最常见的脂质异常。血糖控制不佳和较高的促甲状腺激素值是血脂异常和高甘油三酯血症的重要预测因素。尽管我们的研究中超重和肥胖儿童的比例较低，但体脂百分比是总胆固醇升高和高密度脂蛋白异常的重要预测因素。有趣的是，在年龄小于 10 岁的 28 名儿童中发现了血脂异常，占总研究组的 11.9%。
我们发现 1 型糖尿病儿童血脂异常的患病率较高，包括年龄小于 10 岁的儿童，这强调了需要对这些儿童进行早期筛查和定期监测血脂谱。
