Health Sciences Centre, School of Medicine, University College Dublin, Dublin, Ireland.
Mol Reprod Dev. 2020 Jun;87(6):650-662. doi: 10.1002/mrd.23352. Epub 2020 Jun 7.
An intact embryo-maternal communication is critical for the establishment of a successful pregnancy. To date, a huge number of studies have been performed describing the complex process of embryo-maternal signaling within the uterus. However, recent studies indicate that the early embryo communicates with the oviductal cells shortly after fertilizationand that this is important for the successful establishment of pregnancy. Only if the early embryo is capable to signal the mother within a precise timeframe and to garner a response, will the embryo be able to survive and reach the uterus. This review will give an overview of all the experimental designs which have investigated embryo-maternal interaction in the oviduct. In addition to that, it will provide a comprehensive analysis of the findings to date elucidating the morphological and molecular changes in the oviduct which are induced by the presence of the early embryo highlighting how the tubal responses affect embryo development and survival.
胚胎与母体间的完整通讯对于成功妊娠至关重要。迄今为止，大量研究已经描述了子宫内胚胎与母体信号传递的复杂过程。然而，最近的研究表明，胚胎在受精后不久就与输卵管细胞进行通讯，这对于成功建立妊娠至关重要。只有当早期胚胎能够在精确的时间范围内向母体发出信号并获得母体的响应时，胚胎才能存活并到达子宫。这篇综述将概述所有研究输卵管中胚胎-母体相互作用的实验设计。此外，它还将对迄今为止的研究结果进行全面分析，阐明早期胚胎存在时诱导的输卵管形态和分子变化，突出输卵管反应如何影响胚胎发育和存活。
