Chung Min-Yu, Hwang Jin-Taek, Park Soo-Hyun
Department of Food and Nutrition Gangseo University Seoul Korea.
Food Functionality Research Division Korea Food Research Institute Wanju Korea.
Food Sci Nutr. 2023 May 16;11(8):4409-4418. doi: 10.1002/fsn3.3426. eCollection 2023 Aug.
Onions are rich in bioactive compounds and have been found to prevent various chronic diseases, including obesity. We performed a systematic review and meta-analysis to investigate the antiobesity effect of onions. Studies were identified in PubMed/MEDLINE, Embase, Web of Science, and CENTRAL focusing on clinical trials evaluating the antiobesity effects of onion in obese subjects. The risk of bias in the studies was evaluated using Cochrane's Risk of Bias tool. The effect of onions was analyzed using data from the selected studies, and the results were indicated by weighted mean difference with 95% CI. The static test was used to examine heterogeneity between the studies. A total of 38 studies were reviewed, of which five clinical trials meeting the criteria were selected. As investigational products, onion peels were used in four studies and onions were used in one study. Following systematic review, it was determined that the risk of bias was generally low, and body weight, BMI, waist circumference, and triglyceride levels were significantly reduced in the onion groups compared to the placebo. In conclusion, onion intake had an antiobesity effect by reducing body weight and body fat, and this effect was particularly pronounced with onion peel.
洋葱富含生物活性化合物，已被发现可预防包括肥胖症在内的各种慢性疾病。我们进行了一项系统综述和荟萃分析，以研究洋葱的抗肥胖作用。在PubMed/MEDLINE、Embase、Web of Science和CENTRAL中检索了聚焦于评估洋葱对肥胖受试者抗肥胖作用的临床试验的研究。使用Cochrane偏倚风险工具评估研究中的偏倚风险。利用所选研究的数据分析洋葱的作用，结果以加权平均差和95%置信区间表示。采用静态检验来检查研究之间的异质性。共审查了38项研究，其中选择了5项符合标准的临床试验。作为研究产品，4项研究使用了洋葱皮，1项研究使用了洋葱。经过系统综述，确定偏倚风险总体较低，与安慰剂相比，洋葱组的体重、BMI、腰围和甘油三酯水平显著降低。总之，摄入洋葱具有减轻体重和体脂的抗肥胖作用，且这种作用在洋葱皮中尤为明显。
