[新型冠状病毒肺炎：一种多方面疾病的发病机制]
[COVID-19: Pathogenesis of a multi-faceted disease].
作者信息
Bonny V, Maillard A, Mousseaux C, Plaçais L, Richier Q
机构信息
Interne en DES de pneumologie, Sorbonne-université, France.
Interne en DES de maladies infectieuses, MSc, Université de Paris, France.
出版信息
Rev Med Interne. 2020 Jun;41(6):375-389. doi: 10.1016/j.revmed.2020.05.003. Epub 2020 May 27.
SARS-CoV-2 infection, named COVID-19, can lead to a dysregulated immune response and abnormal coagulation responsible for a viral sepsis. In this review, we specify physiopathological mechanisms of each phase of COVID-19 - viral, immune and pro-thrombotic - notably because they involve different treatment. Finally, we specify the physiopathological mechanisms of organ injury.
感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）会导致冠状病毒病（COVID-19），可引发免疫反应失调和异常凝血，进而导致病毒性脓毒症。在本综述中，我们详细阐述了COVID-19各阶段的生理病理机制——病毒、免疫和促血栓形成机制——尤其是因为它们涉及不同的治疗方法。最后，我们详细阐述了器官损伤的生理病理机制。
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