School of Material Science and Engineering, South China University of Technology, Guangzhou 510006, P. R. China.
National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P. R. China.
ACS Appl Mater Interfaces. 2020 Aug 5;12(31):34505-34513. doi: 10.1021/acsami.0c04666. Epub 2020 Jun 23.
Cancer residues around the surgical site remain a significant cause of treatment failure with cancer recurrence. To prevent cancer recurrence and simultaneously repair surgery-caused defects, it is urgent to develop implantable biomaterials with anticancer ability and good biological activity. In this work, a functionalized implant is successfully fabricated by doping the effective anticancer element selenium (Se) into the potassium-sodium niobate piezoceramic, which realizes the wireless combination of electrotherapy and chemotherapy. Herein, we demonstrate that the Se-doped piezoelectric implant can cause mitochondrial damage by increasing intracellular reactive oxygen species levels and then trigger the caspase-3 pathway to significantly promote apoptosis of osteosarcoma cells . Meanwhile, its good biocompatibility has been verified. These results are of great importance for future deployment of wireless electro- and chemostimulation to modulate biological process around the defective tissue.
手术部位周围的癌症残留仍然是癌症复发导致治疗失败的一个重要原因。为了防止癌症复发并同时修复手术引起的缺陷，迫切需要开发具有抗癌能力和良好生物活性的可植入生物材料。在这项工作中，通过将有效抗癌元素硒（Se）掺杂到钾钠铌酸盐压电陶瓷中，成功制备了功能化植入物，实现了电疗和化疗的无线结合。在这里，我们证明掺杂 Se 的压电植入物可以通过增加细胞内活性氧水平引起线粒体损伤，然后触发 caspase-3 途径，显著促进骨肉瘤细胞凋亡。同时，其良好的生物相容性也得到了验证。这些结果对于未来部署无线电化疗刺激来调节缺陷组织周围的生物过程具有重要意义。
