School of Bio-sciences and Technology, Vellore Institute of Technology, Vellore, 632014, India.
Saveetha Dental College and Hospitals, SIMATS, Chennai, 600077, TN, India.
Colloids Surf B Biointerfaces. 2018 Oct 1;170:280-292. doi: 10.1016/j.colsurfb.2018.06.006. Epub 2018 Jun 5.
Selenium nanoparticles have at present picked up a vital prospect in the field of medicine, due to their inquisitive properties when compared to other selenium compounds. They are comparatively better as anticancer, non- toxic, and biocompatible operators than selenite (SeO) and selenate (SeO) compounds. The mechanism behind the anticancerous property of SeNps is primarily due to the invasion of the apoptotic pathways and cell cycle arrest, which eventually lead to blockage of other pathways. Conjugation or surface modification of selenium nanoparticles enhances its anticancer adequacy by antibiotics, biomolecules or phytochemical compounds present in microbes or plants. Selenium, being an integral part of enzyme like glutathione peroxidase (GPx) and other seleno-chemical compounds, can enhance the chemotherapeutic activity by acting as a functional division of redox center and inhibiting the tissues from cellular damage by ROS. SeNps can open ways to new regular strategies for treating illnesses like malignancy, and this audit expresses the reasons why these nano measured medications can be the following huge achievement as chemotherapeutic operators.
硒纳米粒子在医学领域引起了人们的极大关注，因为与其他硒化合物相比，它们具有独特的性质。硒纳米粒子在抗癌、无毒、生物相容性方面比亚硒酸盐（SeO）和硒酸盐（SeO）化合物更具优势。硒纳米粒子抗癌的机制主要是通过凋亡途径和细胞周期阻滞的入侵，最终导致其他途径的阻断。硒纳米粒子的共轭或表面修饰通过抗生素、生物分子或微生物或植物中存在的植物化学物质增强其抗癌效果。硒作为谷胱甘肽过氧化物酶（GPx）等酶和其他硒化合物的组成部分，可以通过充当氧化还原中心的功能部分并抑制 ROS 引起的细胞损伤来增强化疗活性。硒纳米粒子为治疗癌症等疾病开辟了新的常规策略，这篇综述表达了为什么这些纳米尺度的药物可以成为未来化疗药物的巨大成就。
