Zuo Tingting, Dewanjee Saikat, Zhang Chao, Chakraborty Pratik, Lu Wanxia, Jha Niraj Kumar, Bhattacharya Hiranmoy, Gangopadhyay Moumita, Fleishman Joshua, Jha Saurabh Kumar, Chen Zhe-Sheng
College of Biological Sciences and Technology, Yili Normal University, Yining, 835000, China.
Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, West Bengal, India.
J Exp Clin Cancer Res. 2025 Jun 4;44(1):171. doi: 10.1186/s13046-025-03427-2.
Cancer is one of the deadliest diseases, continually prompting physicians and researchers to investigate safe and effective modalities for its treatment. Piezoelectric nanomaterial is a new class of material with enormous potential for the nanoscale and bidirectional conversion of mechanical strain into electric fields for cancer treatment. In response to ultrasound mechanical strain, a piezopotential and electric field is generated in the tumor microenvironment, which reduces the growth of cancer cells by catalyzing redox reactions and the synthesis of reactive oxygen species. In this review, we discuss the basic concepts and mechanisms of biopiezoelectric nanomaterials as anti-cancer agents. We provide a comprehensive summary of current state-of-the-art piezoelectric nanoparticles as anti-cancer therapies. Lastly, we identify current challenges that must be addressed for the proper clinical development of biopiezoelectric nanomaterial-based anti-cancer agents and provide future perspectives for the development of this technology.
癌症是最致命的疾病之一，不断促使医生和研究人员探索安全有效的治疗方法。压电纳米材料是一类新型材料，在纳米尺度以及将机械应变双向转换为电场用于癌症治疗方面具有巨大潜力。响应超声机械应变，肿瘤微环境中会产生压电势和电场，通过催化氧化还原反应和活性氧的合成来抑制癌细胞生长。在这篇综述中，我们讨论了生物压电纳米材料作为抗癌剂的基本概念和作用机制。我们全面总结了当前作为抗癌疗法的先进压电纳米颗粒。最后，我们确定了基于生物压电纳米材料的抗癌剂在临床合理开发中必须解决的当前挑战，并为该技术的发展提供了未来展望。
