Yamamoto M, Saito S, Sakurada T, Tamura M, Kudo Y, Yoshida K, Kaise K, Kaise N, Fukazawa H, Itagaki Y
Second Department of Internal Medicine, Tohoku University School of Medicine, Japan.
Endocrinol Jpn. 1988 Dec;35(6):833-9. doi: 10.1507/endocrj1954.35.833.
We saw a total of 4 episodes of the recurrence of subacute thyroiditis in 3 patients out of 222. The recurrent episodes were similar to the first episodes of subacute thyroiditis. The titers of various viral antibodies were not increased significantly during the clinical course of the recurrence. Regarding the HLA typing, A26, B35 and C3 were positive in all 3 patients. The association between the occurrence of subacute thyroiditis and the presence of HLA-B35 and C3 has hitherto been reported, although the association of HLA-A26 with recurrent type of subacute thyroiditis was observed and described for the first time in this report. It is suggested that HLA-A26 may somehow be related to the predisposition to the recurrence of subacute thyroiditis which developed after more than 10 years.
在222例患者中，我们共观察到3例患者出现了4次亚急性甲状腺炎复发。复发情况与亚急性甲状腺炎的首次发作相似。在复发的临床过程中，各种病毒抗体的滴度没有显著升高。关于HLA分型，所有3例患者的A26、B35和C3均呈阳性。虽然HLA - B35和C3与亚急性甲状腺炎的发生之间的关联此前已有报道，但本报告首次观察并描述了HLA - A26与亚急性甲状腺炎复发类型之间的关联。提示HLA - A26可能在某种程度上与10多年后发生的亚急性甲状腺炎复发易感性有关。
