The Risk of Recurrence of Subacute Thyroiditis Is HLA-Dependent.

The frequency of recurrence of subacute thyroiditis (SAT) is rather high, reaching 20⁻30%. The reason for SAT relapse is still unknown. Recently, we have demonstrated the association between SAT and the presence of HLA-B18:01, DRB101, and C04:01, apart from the previously known HLA-B35. The aim of the present study was to evaluate the correlation between SAT-associated HLA haplotypes and the risk of SAT recurrence. HLA-A, -B, -C, -DQB1 and -DRB1 were genotyped using a next-generation sequencing method in 49 SAT patients. The patients were divided into the following HLA groups: 1. HLA-B35 and/or HLA-C04, but without any other of the analyzed antigens; 2. HLA-DRB101, regardless of the co-presence of HLA-B35 or -C04:01, but without HLA-B18:01; 3. HLA-B18 only, without any other antigen; 4. HLA-B18:01 plus -B35, regardless of the presence of any other analyzed antigens. The recurrence rate was compared between the groups. The recurrence rate was significantly increased in patients with HLA-B18:01 plus HLA-B35. In conclusion, the risk of SAT recurrence was HLA-dependent and the determining factor was the co-presence of HLA-B18:01 and -B35. In such high-risk patients, the steroid treatment regimen should be intensified with a slower dose reduction.