Hlashwayo Delfina Fernandes, Barbosa Filomena, Langa Sílvia, Sigaúque Betuel, Bila Custódio Gabriel
Departamento de Ciências Biológicas, Faculdade de Ciências, Universidade Eduardo Mondlane, Avenida Julius Nyerere nr 3453, Campus Principal, Maputo, Mozambique.
Faculdade de Veterinária, Universidade Eduardo Mondlane, Avenida de Moçambique, Km 1.5, Maputo, Mozambique.
Evid Based Complement Alternat Med. 2020 May 15;2020:9485364. doi: 10.1155/2020/9485364. eCollection 2020.
spp. are zoonotic bacteria that cause gastroenteritis in humans and may cause extraintestinal infections such as Guillain-Barré syndrome, reactive arthritis, and bacteremia. Resistance to antibiotics is an increasing concern in the Sub-Saharan Africa; thus, search for alternatives such as plant-based active ingredients is important in order to develop new drugs.
To present a systematic review of and studies of the antibacterial activity of medicinal plants from Sub-Saharan Africa against spp. . Studies published until March 2020 on medicinal plants used against spp. from each country of Sub-Saharan Africa were searched on PubMed, Science Direct, AJOL, and Google Scholar. Articles were selected based on the existence of information regarding and activity of medicinal plants against spp.
A total of 47 medicinal plants belonging to 28 families were studied for activity against spp. No plant was studied Plants from Fabaceae family were the most commonly studied. The plants with the strongest antimicrobial activities were and . The root extracts from these plants were effective, and both had a minimal inhibitory concentration (MIC) of 25 g/ml. Seven pure compounds were isolated and analyzed for activity against spp. The compound cryptolepine from was the most effective with MIC values ranging between 6.25 and 25 g/ml.
Several native plants from the Sub-Saharan Africa region were studied for activity against spp. Some plants seemed very effective against the bacteria. Chemical compounds from three plants have been isolated and analyzed, but further studies are needed in order to produce new and effective drugs.
[细菌名称]是一种人畜共患细菌，可导致人类肠胃炎，并可能引发诸如吉兰-巴雷综合征、反应性关节炎和菌血症等肠外感染。在撒哈拉以南非洲，抗生素耐药性问题日益受到关注；因此，寻找植物活性成分等替代物对于开发新药很重要。
对撒哈拉以南非洲药用植物对[细菌名称]的抗菌活性进行系统综述。在PubMed、Science Direct、AJOL和谷歌学术上搜索了截至2020年3月发表的关于撒哈拉以南非洲各国用于对抗[细菌名称]的药用植物的研究。根据有关药用植物对[细菌名称]的[相关指标1]和[相关指标2]活性的信息来选择文章。
共研究了28个科的47种药用植物对[细菌名称]的[相关指标1]活性。未对任何植物进行[相关指标2]研究。豆科植物是研究最普遍的植物。抗菌活性最强的植物是[植物名称1]和[植物名称2]。这些植物的根提取物有效，两者的最低抑菌浓度（MIC）均为25微克/毫升。分离出7种纯化合物并分析其对[细菌名称]的活性。来自[植物名称3]的隐丹参酮化合物最有效，MIC值在6.25至25微克/毫升之间。
对撒哈拉以南非洲地区的几种本土植物进行了对抗[细菌名称]的[相关指标1]活性研究。一些植物对该细菌似乎非常有效。已从三种植物中分离并分析了化合物，但为了生产新的有效药物还需要进一步研究。
