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卡菲利研究中的A型行为与常见心脏病:风险增加还是症状报告?

Type A behaviour and prevalent heart disease in the Caerphilly study: increase in risk or symptom reporting?

作者信息

Gallacher J E, Yarnell J W, Butland B K

机构信息

MRC Epidemiology Unit, Cardiff.

出版信息

J Epidemiol Community Health. 1988 Sep;42(3):226-31. doi: 10.1136/jech.42.3.226.

Abstract

Type A behaviour was assessed by modified Framingham scale in a total sample of 1956 employed men in the Caerphilly study. Prevalent heart disease was measured by cardiovascular questionnaire to obtain evidence of myocardial infarction and angina, and by electrocardiogram (ECG) for evidence of ischaemia. Type A was inversely related to age and systolic blood pressure and was positively related to social class and height. It was not related to serum cholesterol or alcohol consumption. After control for age, systolic blood pressure, height, smoking and social class, type A was found to be independent of angina but positively associated with an increased risk of possible myocardial infarction (MI). Type A was also associated with increased risk of confirmed MI. An inverse association was found between type A and asymptomatic ischaemic heart disease (IHD). The association between type A and symptomatic IHD could be due to symptom reporting.

摘要

在卡菲利研究中,采用改良的弗雷明汉量表对1956名在职男性的总样本进行了A型行为评估。通过心血管问卷测量现患心脏病,以获取心肌梗死和心绞痛的证据,并通过心电图(ECG)获取缺血证据。A型与年龄和收缩压呈负相关,与社会阶层和身高呈正相关。它与血清胆固醇或酒精消费无关。在对年龄、收缩压、身高、吸烟和社会阶层进行控制后,发现A型与心绞痛无关,但与可能发生心肌梗死(MI)的风险增加呈正相关。A型还与确诊MI的风险增加有关。发现A型与无症状缺血性心脏病(IHD)之间存在负相关。A型与有症状IHD之间的关联可能是由于症状报告。

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