严重急性呼吸综合征冠状病毒2通过重组和强烈的纯化选择出现。
Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection.
作者信息
Li Xiaojun, Giorgi Elena E, Marichann Manukumar Honnayakanahalli, Foley Brian, Xiao Chuan, Kong Xiang-Peng, Chen Yue, Korber Bette, Gao Feng
出版信息
bioRxiv. 2020 Mar 22:2020.03.20.000885. doi: 10.1101/2020.03.20.000885.
UNLABELLED
COVID-19 has become a global pandemic caused by a novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis and for drug discovery and vaccine development. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike gene and in other genes among bat, pangolin and human coronaviruses, indicating similar strong evolutionary constraints in different host species. We also demonstrate that SARS-CoV-2's entire RBM was introduced through recombination with coronaviruses from pangolins, possibly a critical step in the evolution of SARS-CoV-2's ability to infect humans. Similar purifying selection in different host species and frequent recombination among coronaviruses suggest a common evolutionary mechanism that could lead to new emerging human coronaviruses.
ONE SENTENCE SUMMARY
Extensive Recombination and Strong Purifying Selection among coronaviruses from different hosts facilitate the emergence of SARS-CoV-2.
未标注
新型冠状病毒SARS-CoV-2引发的COVID-19已成为全球大流行疾病。了解SARS-CoV-2的起源对于预防未来人畜共患病以及药物研发和疫苗开发至关重要。我们展示了在蝙蝠、穿山甲和人类冠状病毒的刺突基因及其他基因中，围绕受体结合基序（RBM）存在强烈纯化选择的证据，这表明在不同宿主物种中存在类似的强大进化限制。我们还证明，SARS-CoV-2的整个RBM是通过与穿山甲冠状病毒的重组引入的，这可能是SARS-CoV-2感染人类能力进化中的关键一步。不同宿主物种中类似的纯化选择以及冠状病毒之间频繁的重组表明存在一种共同的进化机制，可能导致新型人类冠状病毒的出现。
一句话总结
不同宿主冠状病毒之间广泛的重组和强烈的纯化选择促进了SARS-CoV-2的出现。
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