Molina-Ruiz Rosa M, Looi Jeffrey C L, Walterfang Mark, García-Saiz Tomás, Wilkes Fiona A, Liu Lena L, Velakoulis Dennis, Perera Jose Luis Carrasco, Diaz-Marsa Marina
Complutense University Medical School, Hospital Clínico San Carlos, Madrid, Spain.
Research Centre for Neurosciences of Ageing, Academic Unit of Psychiatry and Addiction Medicine, Australian National University Medical School, Canberra. Hospital, Canberra, Australia.
Rev Psiquiatr Salud Ment (Engl Ed). 2020 Jun 5. doi: 10.1016/j.rpsm.2020.01.003.
Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.
We studied 24 female patients: Anorexia Nervosa AN (n=8), Bulimia Nervosa BN (n=9), comorbid ED with borderline personality disorder (EDc; n=7), and a group of Healthy Controls (n=19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).
Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (p=0.008), BN (p<.001) and EDc (p=.001)] and a smaller right putaminal volume in EDc compared to controls (p=.045) and AN (p=.039). Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.
This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. Larger scale studies should be carried out that allow replication of these data.
饮食失调（ED）中暴食和冲动行为的差异在神经生物学水平上与皮质-纹状体回路功能障碍有关。我们试图研究新纹状体体积作为饮食失调亚组中的一种生物标志物，以及它与创伤史之间的可能关系。
我们研究了24名女性患者：神经性厌食症（AN；n = 8）、神经性贪食症（BN；n = 9）、合并边缘性人格障碍的饮食失调（EDc；n = 7），以及一组健康对照者（n = 19）。使用暴饮暴食行为和冲动量表对我们的样本进行特征描述，同时使用创伤问卷以及对尾状核和壳核（纹状体）进行磁共振成像（MRI）体积手动测量。
我们的初步结果显示，与其他三组相比，AN组左侧壳核体积显著更大[对照组（C；p = 0.008）、BN组（p <.001）和EDc组（p = 0.001）]，并且与对照组（p = 0.045）和AN组（p = 0.039）相比，EDc组右侧壳核体积更小。在双侧壳核体积与自我报告的一般创伤和早期创伤评分之间发现了一些负相关。
这项初步研究表明，纹状体体积可能在神经生物学水平上区分AN与BN和EDc，这对治疗策略具有启示意义。应该开展更大规模的研究以复制这些数据。
