Mechanoadaptation and Caveolae Biology Lab, Cell and Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Cancer Metastasis Rev. 2020 Jun;39(2):485-503. doi: 10.1007/s10555-020-09900-y.
Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects of cell function, mechanotransduction, and ECM-cell interaction. Here, we review our current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standing questions in the field.
肿瘤变硬是恶性肿瘤的一个标志，它积极推动肿瘤的进展和侵袭性。最近的研究揭示了这一生物力学过程的几个分子基础，其核心是肿瘤细胞、基质成纤维细胞和细胞外基质重塑之间的相互交流。这种动态的交流塑造了肿瘤微环境；显著决定了包括治疗抵抗、复发或转移在内的疾病特征；并可能为新的抗肿瘤策略提供关键。陷窝和它们的组成部分作为细胞功能、力学转导和细胞外基质-细胞相互作用不同方面的整合者出现。在这里，我们回顾了关于必不可少的陷窝成分窖蛋白-1在这种多向生物力学交流中的几个关键作用的现有知识，并强调了该领域的悬而未决的问题。
