State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University , Beijing, China.
Autophagy. 2020 Jul;16(7):1358-1360. doi: 10.1080/15548627.2020.1768668. Epub 2020 Jun 10.
Macroautophagy/autophagy was recently shown to regulate unconventional protein secretion through a process called secretory autophagy. How the secretory cargo selectively enters into the secretory autophagosome has been a central question. Our recent studies indicate that cargo translocation into the ER-Golgi intermediate compartment, a compartment contributing membranes to the forming autophagosome, acts as a mechanism for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.
自噬最近被证明通过一种称为分泌自噬的过程来调节非常规蛋白质的分泌。分泌货物如何选择性地进入分泌自噬体一直是一个核心问题。我们最近的研究表明，货物易位到内质网-高尔基体中间区室（该区室为正在形成的自噬体提供膜）充当了囊泡中分泌货物进入的机制，并且可能是分泌自噬的早期步骤。
