Instituto de Biomedicina de Valencia (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Jaime Roig 11, 46010 Valencia, Spain.
Department of Biotechnology, Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural (ETSIAMN), Universitat Politècnica de València, 46022 Valencia, Spain.
Int J Mol Sci. 2020 Jun 8;21(11):4096. doi: 10.3390/ijms21114096.
Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function is a common factor that predisposes or contributes to the generation of seizures. At the same time, acute seizures upregulate the production of pro-inflammatory cytokines in microglia and astrocytes, triggering a downstream cascade of inflammatory mediators. Therefore, epileptic seizures and inflammatory mediators form a vicious positive feedback loop, reinforcing each other. In this work, we have reviewed the main glial signaling pathways involved in neuroinflammation, how they are affected in epileptic conditions, and the therapeutic opportunities they offer to prevent these disorders.
神经炎症和癫痫相互关联。脑炎症促进神经元过度兴奋和癫痫发作，而神经胶质免疫炎症功能失调是导致癫痫发作的一个常见因素。同时，急性癫痫发作会在上调小胶质细胞和星形胶质细胞中促炎细胞因子的产生，引发下游炎症介质的级联反应。因此，癫痫发作和炎症介质形成了一个恶性循环，相互加强。在这项工作中，我们回顾了参与神经炎症的主要神经胶质信号通路，以及它们在癫痫状态下是如何受到影响的，以及它们提供了哪些治疗机会来预防这些疾病。
