De-Eknamkul Chawina, Zhang Xingwang, Zhao Meng-Qiang, Huang Wenzhuo, Liu Renyu, Johnson A T Charlie, Cubukcu Ertugrul
Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093-0448, United States of America.
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
2d Mater. 2020 Jan;7(1). doi: 10.1088/2053-1583/ab5ae2. Epub 2019 Dec 11.
Owing to their unique electrical and optical properties, two-dimensional transition metal dichalcogenides have been extensively studied for their potential applications in biosensing. However, simultaneous utilization of both optical and electrical properties has been overlooked, yet it can offer enhanced accuracy and detection versitility. Here, we demonstrate a dual-mode optoelectronic biosensor based on monolayer molybdenum disulfide (MoS) capable of producing simultaneous electrical and optical readouts of biomolecular signals. On a single platform, the biosensor exhibits a tunable photonic Fano-type optical resonance while also functioning as a field-effect transistor (FET) based on a optically transparent gate electrode. Furthermore, chemical vapor deposition grown MoS provides a clean surface for direct immobilization of a water-soluble variant of the -opioid receptor (wsMOR), via a nickel ion-mediated linker chemistry. We utilize a synthetic opioid peptide to show the operation of the electronic and optical sensing modes. The responses of both modes exhibit a similar trend with dynamic ranges of four orders of magnitude and detection limits of <1 nM. Our work explores the potential of a versatile multimodal sensing platform enabled by monolayer MoS, since the integration of electrical and optical sensors on the same chip can offer flexibility in read-out and improve the accuracy in detection of low concentration targets.
由于其独特的电学和光学性质，二维过渡金属二硫属化物因其在生物传感中的潜在应用而受到广泛研究。然而，光学和电学性质的同时利用一直被忽视，而这可以提高准确性和检测通用性。在此，我们展示了一种基于单层二硫化钼（MoS）的双模式光电生物传感器，它能够同时产生生物分子信号的电学和光学读数。在单个平台上，该生物传感器展现出可调谐的光子法诺型光学共振，同时还作为基于光学透明栅电极的场效应晶体管（FET）发挥作用。此外，通过化学气相沉积生长的MoS提供了一个干净的表面，用于通过镍离子介导的连接化学直接固定μ-阿片受体（wsMOR）的水溶性变体。我们利用一种合成阿片肽来展示电子和光学传感模式的运作。两种模式的响应呈现出相似的趋势，动态范围为四个数量级，检测限<1 nM。我们的工作探索了由单层MoS实现的多功能多模态传感平台的潜力，因为在同一芯片上集成电学和光学传感器可以在读取方面提供灵活性，并提高低浓度目标检测的准确性。
