Medical School, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210009, China.
Department of Clinical Laboratory, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Angew Chem Int Ed Engl. 2020 Sep 14;59(38):16747-16754. doi: 10.1002/anie.202007451. Epub 2020 Jul 20.
The exceptional nature of WO dots has inspired widespread interest, but it is still a significant challenge to synthesize high-quality WO dots without using unstable reactants, expensive equipment, and complex synthetic processes. Herein, the synthesis of ligand-free WO dots is reported that are highly dispersible and rich in oxygen vacancies by a simple but straightforward exfoliation of bulk WS and a mild follow-up chemical conversion. Surprisingly, the WO dots emerged as co-reactants for the electrochemiluminescence (ECL) of Ru(bpy) with a comparable ECL efficiency to the well-known Ru(bpy) /tripropylamine (TPrA) system. Moreover, compared to TPrA, whose toxicity remains a critical issue of concern, the WO dots were ca. 300-fold less toxic. The potency of WO dots was further explored in the detection of circulating tumor cells (CTCs) with the most competitive limit of detection so far.
WO 点的特殊性质激发了广泛的兴趣，但在不使用不稳定的反应物、昂贵的设备和复杂的合成工艺的情况下合成高质量的 WO 点仍然是一个重大挑战。在此，通过简单但直接的块状 WS 的剥离和温和的后续化学转化，报道了配体自由 WO 点的合成，其具有高分散性和丰富的氧空位。令人惊讶的是，WO 点成为 Ru(bpy)电化学发光（ECL）的共反应物，其 ECL 效率可与著名的 Ru(bpy)/三丙胺（TPrA）体系相媲美。此外，与毒性仍然是一个关键问题的 TPrA 相比，WO 点的毒性约低 300 倍。WO 点的功效还在迄今最具竞争力的检测循环肿瘤细胞（CTC）的检测中得到了进一步的探索。
