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葡萄牙社区药房针头交换计划的成本与后果。

Costs and consequences of the Portuguese needle-exchange program in community pharmacies.

作者信息

Borges Margarida, Gouveia Miguel, Fiorentino Francesca, Jesus Gonçalo, Cary Maria, Guerreiro José Pedro, Costa Suzete, Carneiro António Vaz

机构信息

Faculdade de Medicina (Borges, Fiorentino, Jesus, Vaz Carneiro), Universidade de Lisboa.

Laboratório de Farmacologia Clínica e Terapêutica, Unidade de Farmacologia Clínica, Centro Hospitalar Lisboa Central EPE (Borges).

出版信息

Can Pharm J (Ott). 2020 May 12;153(3):170-178. doi: 10.1177/1715163520915744. eCollection 2020 May-Jun.

Abstract

BACKGROUND

Needle-exchange programs (NEPs) reduce infections in people who inject drugs. This study assesses the impact community pharmacies have had in the Needle-Exchange Program in Portugal since 2015.

METHODS

Health gains were measured by the number of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections averted, which were estimated, in each scenario, based on a standard model in the literature, calibrated to national data. The costs per infection were taken from national literature; costs of manufacturing, logistics and incineration of injection materials were also considered. The results were presented as net costs (i.e., incremental costs of the program with community pharmacies less the costs of additional infections avoided).

RESULTS

Considering a 5-year horizon, the Needle Exchange Program with community pharmacies would account for a 6.8% ( = 25) and a 6.5% reduction ( = 22) of HCV and HIV infections, respectively. The present value of net savings generated by the participation of community pharmacies in the program was estimated at €2,073,347. The average discounted net benefit per syringe exchanged is €3.01, already taking into account a payment to community pharmacies per needle exchanged.

INTERPRETATION

We estimate that the participation of community pharmacies in the Needle Exchange Program will lead to a reduction of HIV and HCV infections and will generate over €2 million in savings for the health system.

CONCLUSIONS

The intervention is estimated to generate better health outcomes at lower costs, contributing to improving the efficiency of the public health system in Portugal.

摘要

背景

针头交换项目(NEPs)可减少注射吸毒者的感染。本研究评估了自2015年以来社区药房在葡萄牙针头交换项目中所产生的影响。

方法

通过避免的人类免疫缺陷病毒(HIV)和丙型肝炎病毒(HCV)感染数量来衡量健康收益,在每种情况下,根据文献中的标准模型并校准为国家数据进行估算。每次感染的成本取自国家文献;还考虑了注射材料的制造、物流和焚烧成本。结果以净成本呈现(即,有社区药房参与的项目的增量成本减去避免额外感染的成本)。

结果

考虑到5年的时间范围,有社区药房参与的针头交换项目将分别使HCV和HIV感染减少6.8%(=25例)和6.5%(=22例)。社区药房参与该项目所产生的净节省的现值估计为2,073,347欧元。每交换一支注射器的平均贴现净收益为3.01欧元,这已经考虑了向社区药房支付的每支交换针头的费用。

解读

我们估计社区药房参与针头交换项目将减少HIV和HCV感染,并为卫生系统节省200多万欧元。

结论

据估计,该干预措施能以较低成本产生更好的健康结果,有助于提高葡萄牙公共卫生系统的效率。

相似文献

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Costs and consequences of the Portuguese needle-exchange program in community pharmacies.葡萄牙社区药房针头交换计划的成本与后果。
Can Pharm J (Ott). 2020 May 12;153(3):170-178. doi: 10.1177/1715163520915744. eCollection 2020 May-Jun.

本文引用的文献

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Chronic hepatitis C treated with peginterferon alfa plus ribavirin in clinical practice.
Hepatogastroenterology. 2011 Jul-Aug;58(109):1260-6. doi: 10.5754/hge10239.
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Costs and effectiveness of a syringe distribution and needle exchange program for HIV prevention in a regional setting.
Eur J Health Econ. 2003 Sep;4(3):203-8. doi: 10.1007/s10198-003-0172-7. Epub 2003 Jul 1.

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