Akdogan-Ozdilek Bagdeser, Duval Katherine L, Goll Mary G
Department of Genetics, University of Georgia, Athens, GA, USA.
F1000Res. 2020 Apr 28;9. doi: 10.12688/f1000research.21809.1. eCollection 2020.
Early animal development is characterized by intense reorganization of the embryonic genome, including large-scale changes in chromatin structure and in the DNA and histone modifications that help shape this structure. Particularly profound shifts in the chromatin landscape are associated with the maternal-to-zygotic transition, when the zygotic genome is first transcribed and maternally loaded transcripts are degraded. The accessibility of the early zebrafish embryo facilitates the interrogation of chromatin during this critical window of development, making it an important model for early chromatin regulation. Here, we review our current understanding of chromatin dynamics during early zebrafish development, highlighting new advances as well as similarities and differences between early chromatin regulation in zebrafish and other species.
早期动物发育的特点是胚胎基因组的强烈重组，包括染色质结构以及有助于塑造这种结构的DNA和组蛋白修饰的大规模变化。染色质格局的特别深刻变化与母源-合子转变相关，此时合子基因组首次转录，母源加载的转录本被降解。早期斑马鱼胚胎的可及性便于在这个关键的发育窗口期间对染色质进行研究，使其成为早期染色质调控的重要模型。在这里，我们综述了目前对斑马鱼早期发育过程中染色质动态的理解，强调了新进展以及斑马鱼与其他物种早期染色质调控之间的异同。
