研究癌症中神经影响的临床可操作策略。

Clinically Actionable Strategies for Studying Neural Influences in Cancer.

机构信息

Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany; Department of General Surgery, HPB-Unit, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany; CRC 1321 Modelling and Targeting Pancreatic Cancer, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany; CRC 1321 Modelling and Targeting Pancreatic Cancer, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

出版信息

Cancer Cell. 2020 Jul 13;38(1):11-14. doi: 10.1016/j.ccell.2020.05.023. Epub 2020 Jun 11.

DOI:10.1016/j.ccell.2020.05.023

PMID:32531270

Abstract

Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating these findings from bench to the clinic.

摘要

神经胶质细胞激活是最近发现的肿瘤生长的一个特征。在临床前和小型临床试验中针对肿瘤过度神经支配进行靶向治疗已经产生了有希望的抗肿瘤效果，这凸显了系统分析癌症中的神经影响（NIC）的必要性。在这里，我们概述了将这些发现从实验室转化为临床的策略。