使用氰乙基亚磷酰胺前体对磷脂酰甘油进行立体定向合成。
Stereospecific synthesis of phosphatidylglycerol using a cyanoethyl phosphoramidite precursor.
作者信息
Struzik Zachary J, Weerts Ashley N, Storch Judith, Thompson David H
机构信息
Department of Chemistry, Purdue University, Multi-disciplinary Cancer Research Facility, Bindley Bioscience Center, 1203 W. State Street, West Lafayette, IN 47907, United States.
Department of Nutritional Sciences and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, United States.
出版信息
Chem Phys Lipids. 2020 Sep;231:104933. doi: 10.1016/j.chemphyslip.2020.104933. Epub 2020 Jun 11.
Abstract
Phosphatidylglycerols (PG) are a family of naturally occurring phospholipids that are responsible for critical operations within cells. PG are characterized by an (R) configuration in the diacyl glycerol backbone and an (S) configuration in the phosphoglycerol head group. Herein, we report a synthetic route to provide control over the PG stereocenters as well as control of the acyl chain identity.
摘要
磷脂酰甘油（PG）是一类天然存在的磷脂，负责细胞内的关键运作。PG的特征在于二酰甘油主链中的（R）构型和磷酸甘油头部基团中的（S）构型。在此，我们报告了一种合成路线，用于控制PG的立体中心以及酰基链的特性。
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