自主神经药物和前列腺素对大鼠下颌下腺唾液腺泡22Na摄取的对比作用。

Contrasting effects of autonomic agents and prostaglandins on 22Na uptake in rat submandibular salivary acini.

作者信息

Martinez J R, Barker S

机构信息

Department of Child Health, University of Missouri School of Medicine, Columbia 65212.

出版信息

Arch Oral Biol. 1988;33(8):621-2. doi: 10.1016/0003-9969(88)90139-2.

DOI:10.1016/0003-9969(88)90139-2

PMID:3254131

Abstract

Uptake of this isotopic tracer by the acini occurred in a time-dependent manner and was increased by 1 microM concentrations of acetylcholine and of isoproterenol, but not of prostaglandins E1, E2 and F2 alpha. The lack of effect of prostaglandins on Na transport in salivary acini contrasts with their inhibitory effect on salivation in vivo, suggesting that in vivo the effects are independent of the ion-transport mechanisms underlying saliva formation.

摘要

腺泡对这种同位素示踪剂的摄取呈时间依赖性，并且在乙酰胆碱和异丙肾上腺素浓度为1微摩尔时摄取增加，但前列腺素E1、E2和F2α不会使其增加。前列腺素对唾液腺泡中钠转运缺乏影响，这与其对体内唾液分泌的抑制作用形成对比，表明在体内这些作用独立于唾液形成的离子转运机制。