Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain.
Rheumatology Division, Hospital Comarcal de Laredo, Laredo, Spain.
Sci Rep. 2020 Jun 15;10(1):9636. doi: 10.1038/s41598-020-66816-x.
Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA.
心血管疾病是轴性脊柱关节炎（axSpA）患者的主要致死原因。脂肪因子失调会增加心血管风险。在与 axSpA 不同的情况下，低网膜素水平与代谢功能障碍和心血管疾病相关。因此，我们评估了网膜素在 385 例 axSpA 患者的心血管风险和亚临床动脉粥样硬化中的遗传和功能意义。通过颈动脉超声评估亚临床动脉粥样硬化。在 385 例患者和 84 例对照中，对与心血管风险相关的多态性连锁不平衡的网膜素 rs12409609 进行基因分型。还测定了血清网膜素水平。在亚组个体中评估了网膜素 mRNA 的表达。与对照组相比，axSpA 患者的血清和 mRNA 网膜素水平较低。低血清网膜素水平与男性、肥胖、炎症性肠病（IBD）和高致动脉粥样硬化指数有关。rs12409609 次要等位基因与 axSpA 中低网膜素 mRNA 表达相关。在遗传或功能水平上，均未观察到与亚临床动脉粥样硬化的相关性。总之，在我们的研究中，axSpA 患者低血清网膜素水平与心血管危险因素相关。此外，rs12409609 次要等位基因可能下调网膜素的表达。这些数据支持网膜素作为 axSpA 心血管风险生物标志物的作用。
