School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Biomacromolecules. 2020 Jul 13;21(7):2574-2594. doi: 10.1021/acs.biomac.0c00566. Epub 2020 Jun 28.
Hydrogels prepared from natural polymers have captured extensive attention over the past decades because of their exceptional biocompatibility and nontoxicity, ease of gelation, and functionalization. Thus, natural polymer hydrogels are considered as promising biomaterials that show great potential in the biomedical field. In drug-delivery systems, the extent and the rate with which the drugs reach their targets are highly carrier-dependent, so the demand for intelligent drug-delivery systems is gradually increasing. Recently, natural polymer hydrogels functionalized with magnetic materials have been used as a novel smart response device for drug delivery because of the quick response and remote controllability. This review aims to give the latest advances of magnetic hydrogels based on natural polymers such as polysaccharide, protein, and DNA in drug-delivery systems. Specifically, the first part compares several general synthesis strategies of magnetic natural polymer hydrogels. The applications of magnetic natural polymer hydrogels are described in the second part. For the last part, an overview of the application in drug delivery for the magnetic hydrogels constructed from several representative natural polymers is presented.
天然聚合物水凝胶因其优异的生物相容性和无毒、易于凝胶化和功能化而在过去几十年中引起了广泛关注。因此，天然聚合物水凝胶被认为是有前途的生物材料，在生物医学领域具有巨大的潜力。在药物传递系统中，药物到达其靶标的程度和速度高度依赖于载体，因此对智能药物传递系统的需求逐渐增加。最近，具有磁性材料功能化的天然聚合物水凝胶已被用作一种新型智能药物传递响应装置，因为其具有快速响应和远程可控性。本综述旨在介绍基于多糖、蛋白质和 DNA 等天然聚合物的磁性水凝胶在药物传递系统中的最新进展。具体来说，第一部分比较了几种磁性天然聚合物水凝胶的一般合成策略。第二部分描述了磁性天然聚合物水凝胶的应用。最后一部分概述了由几种代表性天然聚合物构建的磁性水凝胶在药物传递中的应用。
