State University of Maringá, Department of Chemistry, Av. Colombo, 5790, Jardim Universitário, 87020-900 Maringá, PR, Brazil.
State University of Maringá, Department of Chemistry, Av. Colombo, 5790, Jardim Universitário, 87020-900 Maringá, PR, Brazil.
Carbohydr Polym. 2022 Sep 15;292:119665. doi: 10.1016/j.carbpol.2022.119665. Epub 2022 May 27.
This review reports recent advances in polysaccharide-based magnetic hydrogels as smart platforms for different biomedical applications. These hydrogels have proved to be excellent, viable, eco-friendly alternative materials for the biomedical field due to their biocompatibility, biodegradability, and possibility of controlling delivery processes via modulation of the remote magnetic field. We first present their main synthesis methods and compare their advantages and disadvantages. Next, the synergic properties of hydrogels prepared with polysaccharides and magnetic nanoparticles (MNPs) are discussed. Finally, we describe the main contributions of polysaccharide-based magnetic hydrogels in the targeted drug delivery, tissue regeneration, and hyperthermia therapy fields. Overall, this review aims to motivate the synthesis of novel composite biomaterials, based on the combination of magnetic nanoparticles and natural polysaccharides, to overcome challenges that still exist in the treatment of several diseases.
本综述报告了基于多糖的磁性水凝胶作为不同生物医学应用的智能平台的最新进展。由于其生物相容性、生物可降解性以及通过调节远程磁场来控制输送过程的可能性，这些水凝胶已被证明是生物医学领域中极好的、可行的、环保的替代材料。我们首先介绍了它们的主要合成方法，并比较了它们的优缺点。接下来，讨论了多糖和磁性纳米粒子（MNPs）制备的水凝胶的协同性能。最后，描述了基于多糖的磁性水凝胶在靶向药物输送、组织再生和热疗治疗领域的主要贡献。总的来说，本综述旨在激发基于磁性纳米粒子和天然多糖结合的新型复合生物材料的合成，以克服在治疗几种疾病方面仍然存在的挑战。
