巴西利什曼原虫引起的皮肤利什曼病患者的CD8 T细胞激活炎性小体在疾病免疫发病机制中的作用 - Suppr

Inflammasome Activation by CD8 T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease.

作者信息

Cardoso Thiago Marconi, Lima Jonilson B, Bonyek-Silva Ícaro, Nunes Sara, Feijó Daniel, Almeida Hugo, Silva Juliana, Barral Aldina, Boaventura Viviane, Borges Valéria M, Zamboni Dario S, Pedreira de Carvalho Lucas, Carvalho Edgar M, Tavares Natalia M, Brodskyn Cláudia

机构信息

Fiocruz-BA, Instituto Gonçalo Moniz, Salvador, Bahia, Brazil; Serviço de Imunologia, Hospital Universitário Prof Edgar Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais - Instituto Nacional de Ciência e Tecnologia em - Doenças Tropicais (Conselho Nacional de Pesquisa/Ministério da Ciência e Tecnologia), Salvador, Bahia, Brazil.

Centro de Ciências Biológicas e da Saúde, Universidade Federal do Oeste da Bahia (UFOB).

出版信息

J Invest Dermatol. 2021 Jan;141(1):209-213.e2. doi: 10.1016/j.jid.2020.05.106. Epub 2020 Jun 13.

DOI:10.1016/j.jid.2020.05.106

PMID:32544477

Abstract

摘要

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Inflammasome Activation by CD8 T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease.巴西利什曼原虫引起的皮肤利什曼病患者的CD8 T细胞激活炎性小体在疾病免疫发病机制中的作用

J Invest Dermatol. 2021 Jan;141(1):209-213.e2. doi: 10.1016/j.jid.2020.05.106. Epub 2020 Jun 13.

Contribution of Leishmania braziliensis antigen-specific CD4+ T, CD8+ T, NK and CD3+CD56+NKT cells in the immunopathogenesis of cutaneous leishmaniasis patients: Cytotoxic, activation and exhaustion profiles.巴西利什曼原虫抗原特异性 CD4+T、CD8+T、NK 和 CD3+CD56+NKT 细胞在皮肤利什曼病患者免疫发病机制中的贡献：细胞毒性、激活和耗竭特征。

PLoS One. 2020 Mar 23;15(3):e0229400. doi: 10.1371/journal.pone.0229400. eCollection 2020.

CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.CD8 + T细胞的细胞毒性通过炎性小体激活和白细胞介素-1β的产生介导皮肤病理变化。

PLoS Pathog. 2017 Feb 13;13(2):e1006196. doi: 10.1371/journal.ppat.1006196. eCollection 2017 Feb.

Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil.巴西亚马逊地区由利什曼原虫（维安尼亚亚属）引起的人类皮肤利什曼病病变的免疫病理学特征

Parasitol Res. 2017 May;116(5):1423-1431. doi: 10.1007/s00436-017-5403-4. Epub 2017 Feb 21.

T-cell responsiveness of American cutaneous leishmaniasis patients to purified Leishmania pifanoi amastigote antigens and Leishmania braziliensis promastigote antigens: immunologic patterns associated with cure.美洲皮肤利什曼病患者对纯化的皮氏利什曼原虫无鞭毛体抗原和巴西利什曼原虫前鞭毛体抗原的T细胞反应性：与治愈相关的免疫模式

Exp Parasitol. 1996 Nov;84(2):144-55. doi: 10.1006/expr.1996.0100.

Immunogenicity of Potential CD4 and CD8 T Cell Epitopes Derived From the Proteome of .潜在 CD4 和 CD8 T 细胞表位的免疫原性来源于. 的蛋白质组

Front Immunol. 2020 Feb 14;10:3145. doi: 10.3389/fimmu.2019.03145. eCollection 2019.

The skin homing receptor cutaneous leucocyte-associated antigen (CLA) is up-regulated by Leishmania antigens in T lymphocytes during active cutaneous leishmaniasis.在活动性皮肤利什曼病期间，皮肤归巢受体皮肤白细胞相关抗原（CLA）在T淋巴细胞中被利什曼原虫抗原上调。

Clin Exp Immunol. 2009 Sep;157(3):377-84. doi: 10.1111/j.1365-2249.2009.03970.x.

CD8(+) granzyme B(+)-mediated tissue injury vs. CD4(+)IFNγ(+)-mediated parasite killing in human cutaneous leishmaniasis.CD8(+)颗粒酶 B(+)介导的组织损伤与 CD4(+)IFNγ(+)介导的寄生虫杀伤在人类皮肤利什曼病中的作用。

J Invest Dermatol. 2013 Jun;133(6):1533-40. doi: 10.1038/jid.2013.4. Epub 2013 Jan 15.

Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure.巴西利什曼原虫抗原片段刺激皮肤利什曼病患者细胞的细胞免疫反应评价：在临床治愈前后。

Cell Immunol. 2012 Oct;279(2):180-6. doi: 10.1016/j.cellimm.2012.11.006. Epub 2012 Nov 29.

Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.与人类皮肤利什曼病治愈相关的利什曼原虫反应性CD4+和CD8+ T细胞。

Infect Immun. 1994 Jun;62(6):2614-8. doi: 10.1128/iai.62.6.2614-2618.1994.

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Lesional senescent CD4 T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis.病变衰老的 CD4 T 细胞介导旁观者细胞溶解，并导致人类皮肤利什曼病的皮肤病理学变化。

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Mechanisms regulating host cell death during infection.调控感染过程中宿主细胞死亡的机制。

mBio. 2024 Nov 13;15(11):e0198023. doi: 10.1128/mbio.01980-23. Epub 2024 Oct 11.

Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection.Gasdermin-D激活促进NLRP3激活以及宿主对利什曼原虫感染的抵抗力。

Nat Commun. 2023 Feb 24;14(1):1049. doi: 10.1038/s41467-023-36626-6.

Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis.自身免疫性疾病中 DAMPs 和细胞死亡的作用：以多发性硬化症为例。

Genes Immun. 2023 Apr;24(2):57-70. doi: 10.1038/s41435-023-00198-8. Epub 2023 Feb 7.

Distinct plasma chemokines and cytokines signatures in -infected patients with cutaneous leishmaniasis.- 感染患者的血浆趋化因子和细胞因子特征明显不同。

Front Immunol. 2022 Aug 25;13:974051. doi: 10.3389/fimmu.2022.974051. eCollection 2022.

Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis.阻断 TLR2 和 TLR4 可减轻皮肤利什曼病的炎症反应和寄生虫载量。

Front Immunol. 2021 Oct 6;12:706510. doi: 10.3389/fimmu.2021.706510. eCollection 2021.

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Inflammasome Activation by CD8 T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease.

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