Caruso Angela, Ricceri Laura, Scattoni Maria Luisa
Research Coordination and Support Service, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
Neurosci Biobehav Rev. 2020 Sep;116:31-43. doi: 10.1016/j.neubiorev.2020.06.011. Epub 2020 Jun 13.
In rodent models of Autism Spectrum Disorders (ASD), the study of ultrasonic vocalizations has provided the unique opportunity to evaluate social communication and interaction in ethologically-appropriate contexts, behavioral domains relevant to the first core symptom of ASD. In the present review, we selected and evaluated ultrasonic vocalizations' data collected in rodent models of ASD in different experimental settings, either in the neonatal phase or in adulthood. Both quantitative (calling rates) and qualitative (range and shape of the vocal repertoire) abnormalities have been evidenced. The aim of our work was to highlight several promises and a few caveats in the use of ultrasonic vocalizations for behavioral phenotyping of ASD models and give some suggestions to maximize the translational value of these studies.
在自闭症谱系障碍（ASD）的啮齿动物模型中，对超声波发声的研究提供了独特的机会，可在符合行为学的情境中评估社交沟通与互动，这些行为领域与ASD的首个核心症状相关。在本综述中，我们挑选并评估了在不同实验环境下，于新生期或成年期收集的ASD啮齿动物模型的超声波发声数据。定量（发声率）和定性（发声 repertoire 的范围和形状）异常均已得到证实。我们工作的目的是强调在将超声波发声用于ASD模型行为表型分析时的一些前景和一些注意事项，并给出一些建议，以最大化这些研究的转化价值。
