COVID-19 疗法和抗癌药物：近期文献的系统评价。
COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature.
机构信息
Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy; Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy.
Unit of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Via Mariano Semmola, Naples, Italy.
出版信息
Crit Rev Oncol Hematol. 2020 Aug;152:102991. doi: 10.1016/j.critrevonc.2020.102991. Epub 2020 May 21.
BACKGROUND
It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19).
METHODS
We conducted a literature review on https://www.ncbi.nlm.nih.gov/pubmed/, https://scholar.google.com, www.arxiv.org, www.biorxiv.org, of all articles published using the keywords COVID-19 therapy or treatment and cancer until May 2, 2020. A total of 205 articles were identified and 53 were included in this review.
RESULTS
We describe the ongoing COVID-19 therapies that should be known by oncologists and highlight the potential interactions with antineoplastic drugs, commonly used in clinical practice. The main drug interactions were found with tocilizumab, ruxolitinib and colchicine.
CONCLUSIONS
The literature provides an inconclusive picture on potential preferred treatments for COVID-19 and their interactions with antineoplastic agents. Future clinical trials are needed to better understand the interactions between different drugs in the context of COVID-19 pandemic.
背景
如果癌症患者对冠状病毒病 2 型（COVID-19）呈阳性，那么他们在接受化疗、靶向治疗或免疫治疗时，病情可能更具侵袭性，这是有道理的。
方法
我们在 https://www.ncbi.nlm.nih.gov/pubmed/、https://scholar.google.com、www.arxiv.org、www.biorxiv.org 上对截至 2020 年 5 月 2 日使用 COVID-19 治疗或疗法和癌症等关键词发表的所有文章进行了文献综述。共确定了 205 篇文章，其中 53 篇纳入本综述。
结果
我们描述了肿瘤学家应该了解的正在进行的 COVID-19 疗法，并强调了它们与临床上常用的抗肿瘤药物的潜在相互作用。主要的药物相互作用发生在托珠单抗、鲁索利替尼和秋水仙碱之间。
结论
文献对 COVID-19 的潜在首选治疗方法及其与抗肿瘤药物的相互作用提供了不确定的结果。需要进行未来的临床试验，以更好地了解 COVID-19 大流行背景下不同药物之间的相互作用。
Zotero 插件