Center for Nutraceuticals and Dietary Supplement Research, School of Health Studies, 106 Roane Fieldhouse, University of Memphis, Memphis, TN 38152, USA.
Nutrients. 2020 Jun 11;12(6):1751. doi: 10.3390/nu12061751.
Certain dietary fibers have been reported to improve gut health and cellular immunity. Ambrotose is a glyconutrient supplement that contains mannose-rich polysaccharides (acemannan), reported to improve immune function. A more nutrient-dense version of this dietary supplement has been developed recently, with added aloe leaf gel powder (acemannan). The purpose of this study was to evaluate the impact of the traditional and newly developed Ambrotose products on immunity, gut health, and psychological well-being in healthy men and women.
Seventy-five men and women were randomly assigned in double-blind manner to one of five treatments, as follows: Ambrotose Advanced (AA) at 2 or 4 g daily, Ambrotose LIFE (AL) at 2 or 4 g daily, or placebo. Subjects ingested their assigned treatment daily for eight weeks. Resting heart rate, blood pressure, and measures of psychological well-being were analyzed before and after four and eight weeks of supplementation. Blood samples were collected at the same times and analyzed for zonulin, hematology measures, and cytokines-IL-6, IL-10, IL-1β, and TNF-α (analyzed both with and without stimulation via lipopolysaccharide [LPS]).
All Ambrotose treatments were well-tolerated. There were no differences among treatments in heart rate or blood pressure across time. Self-reported well-being scores were generally higher for the Ambrotose treatments but there were no changes of statistical significance across time ( > 0.05). Differences of statistical significance were noted for select biochemical variables, the most notable being a dramatic decrease in monocytes in the Ambrotose groups. No change was noted in the cytokine response to LPS stimulation in all groups, indicating a maintenance of a healthy immune response. Regular supplementation with Ambrotose is safe and can improve subclinical cellular adversity (as evidenced by a decrease in monocytes), without unnecessary activation of an immune response.
某些膳食纤维已被报道可改善肠道健康和细胞免疫。 Ambrotose 是一种含有甘露糖丰富的多糖（乙酰甘露聚糖）的糖营养素补充剂，据报道可改善免疫功能。最近开发了一种营养更密集的这种膳食补充剂，添加了芦荟叶凝胶粉（乙酰甘露聚糖）。本研究的目的是评估传统和新开发的 Ambrotose 产品对健康男性和女性的免疫、肠道健康和心理健康的影响。
75 名男性和女性随机分为五组，以双盲方式接受以下治疗之一：每天 2 或 4 克 Ambrotose Advanced（AA）、每天 2 或 4 克 Ambrotose LIFE（AL）或安慰剂。受试者每天摄入指定的治疗，持续八周。在补充四周和八周前后分析静息心率、血压和心理健康测量结果。在相同时间采集血液样本，分析 zonulin、血液学指标以及细胞因子-IL-6、IL-10、IL-1β和 TNF-α（分别用和不用脂多糖[LPS]刺激分析）。
所有 Ambrotose 治疗均耐受良好。在整个时间内，心率或血压在治疗组之间没有差异。自我报告的幸福感评分通常在 Ambrotose 治疗组中较高，但在整个时间内没有统计学意义上的变化（>0.05）。一些生化变量的差异具有统计学意义，最显著的是 Ambrotose 组单核细胞数量明显减少。所有组的 LPS 刺激后的细胞因子反应没有变化，表明维持了健康的免疫反应。定期补充 Ambrotose 是安全的，可以改善亚临床细胞逆境（如单核细胞减少），而不会不必要地激活免疫反应。
