Buonfrate Dora, Bisanzio Donal, Giorli Giovanni, Odermatt Peter, Fürst Thomas, Greenaway Christina, French Michael, Reithinger Richard, Gobbi Federico, Montresor Antonio, Bisoffi Zeno
Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, 37024 Verona, Italy.
RTI International, Washington, DC 20005, USA.
Pathogens. 2020 Jun 13;9(6):468. doi: 10.3390/pathogens9060468.
Strongyloidiasis is a common neglected tropical disease in tropical and sub-tropical climatic zones. At the worldwide level, there is high uncertainty about the strongyloidiasis burden. This uncertainty represents an important knowledge gap since it affects the planning of interventions to reduce the burden of strongyloidiasis in endemic countries. This study aimed to estimate the global strongyloidiasis prevalence. A literature review was performed to obtain prevalence data from endemic countries at a worldwide level from 1990 to 2016. For each study, the true population prevalence was calculated by accounting for the specificity and the sensitivity of testing and age of tested individuals. Prediction of strongyloidiasis prevalence for each country was performed using a spatiotemporal statistical modeling approach. The country prevalence obtained from the model was used to estimate the number of infected people per country. We estimate the global prevalence of strongyloidiasis in 2017 to be 8.1% (95% CI: 4.2-12.4%), corresponding to 613.9 (95% CI: 313.1-910.1) million people infected. The South-East Asia, African, and Western Pacific Regions accounted for 76.1% of the global infections. Our results could be used to identify those countries in which strongyloidiasis prevalence is highest and where mass drug administration (MDA) should be deployed for its prevention and control.
类圆线虫病是热带和亚热带气候区一种常见的被忽视的热带病。在全球范围内，类圆线虫病负担存在高度不确定性。这种不确定性代表了一个重要的知识空白，因为它影响到在流行国家减轻类圆线虫病负担的干预措施规划。本研究旨在估计全球类圆线虫病患病率。进行了一项文献综述，以获取1990年至2016年全球范围内流行国家的患病率数据。对于每项研究，通过考虑检测的特异性和敏感性以及受测个体的年龄来计算真实的人群患病率。使用时空统计建模方法对每个国家的类圆线虫病患病率进行预测。从模型中获得的国家患病率用于估计每个国家的感染人数。我们估计2017年全球类圆线虫病患病率为8.1%（95%置信区间：4.2 - 12.4%），相当于6.139亿（95%置信区间：3.131 - 9.101亿）人感染。东南亚、非洲和西太平洋地区占全球感染人数的76.1%。我们的结果可用于确定类圆线虫病患病率最高的国家，以及应在哪些国家开展群体药物治疗（MDA）以进行预防和控制。
