Yao Litong, Zhong Yifan, He Lingzi, Wang Yan, Wu Jingyang, Geng Jin, Zhou Yun, Zhang Jiahua, Chen Jun, Shan Zhongyan, Teng Weiping, Xu Yingying, Chen Lei, Liu Lei
China Medical University, Shenyang 110001, People's Republic of China.
Department of Breast Surgery, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 May 22;13:1803-1812. doi: 10.2147/DMSO.S250928. eCollection 2020.
To investigate the association between serum carbohydrate antigen 125 (CA125) and the presence as well as severity of diabetes retinopathy (DR) in Chinese adult patients with type 2 diabetes.
A hospital-based cross-sectional study was conducted from February 2012 to November 2018. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. Vision-threatening DR (VTDR) was diagnosed if subjects had severe non-proliferative DR (NPDR), proliferative DR (PDR), or clinically significant macular edema (CSME). Multivariate logistic regression models were applied to explore the associations.
Among the 2696 participants, the overall prevalence of DR was 25.1%, of which the prevalence of mild NPDR, moderate NPDR, and VTDR was 10.8%, 4.5%, and 9.9%, respectively. Serum CA125 level was significantly higher in participants with DR and increased with the severity of DR ( = 0.013). After accounting for age, gender, smoking, drinking, duration of diabetes, anti-diabetic agents use, systolic blood pressure, pulse pressure, weight, hemoglobin A1c and fasting plasma glucose levels, CA125 level was significantly associated with subjects in any-severity DR (odds ratio [OR] 1.006 [95% confidence interval CI: 1.002-1.010], = 0.006) and VTDR (1.008 [1.003-1.013], = 0.001). When CA125 was treated as categorized variables, the prevalence of VTDR might increase as improving CA125 quartiles ( value for trend = 0.017).
In this study, serum CA125 level was associated with the presence and severity of DR in Chinese patients with type 2 diabetes. Further prospective studies should be warranted to validate the feasible role of CA125 as well as other biomarkers.
探讨中国成年2型糖尿病患者血清糖类抗原125（CA125）与糖尿病视网膜病变（DR）的发生及严重程度之间的关联。
2012年2月至2018年11月进行了一项基于医院的横断面研究。采用糖尿病视网膜病变早期治疗研究标准评估DR。如果受试者患有严重非增殖性DR（NPDR）、增殖性DR（PDR）或临床显著性黄斑水肿（CSME），则诊断为威胁视力的DR（VTDR）。应用多因素逻辑回归模型探讨其关联。
在2696名参与者中，DR的总体患病率为25.1%，其中轻度NPDR、中度NPDR和VTDR的患病率分别为10.8%、4.5%和9.9%。DR患者的血清CA125水平显著更高，且随DR严重程度增加而升高（P = 0.013）。在考虑年龄、性别、吸烟、饮酒、糖尿病病程、抗糖尿病药物使用、收缩压、脉压、体重、糖化血红蛋白和空腹血糖水平后，CA125水平与任何严重程度的DR患者显著相关（比值比[OR] 1.006 [95%置信区间CI：1.002 - 1.010]，P = 0.006）以及VTDR患者（1.008 [1.003 - 1.013]，P = 0.001）。当将CA125视为分类变量时，VTDR的患病率可能随着CA125四分位数的升高而增加（趋势P值 = 0.017）。
在本研究中，血清CA125水平与中国2型糖尿病患者DR的发生及严重程度相关。应进行进一步的前瞻性研究以验证CA125以及其他生物标志物的可行作用。
