Jamal Albina, Ahmad Irshad, Ahamed Nisar, Azharuddin Muhammad, Alam Farhan, Hussain M Ejaz
Center for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia (A Central University), New Delhi, India.
J Diabetes Metab Disord. 2019 Dec 21;19(1):61-69. doi: 10.1007/s40200-019-00476-1. eCollection 2020 Jun.
The aim of the study was to determine the efficacy of whole body vibration (WBV) therapy on pain, neuropathy disability score, balance, proprioception and quality of life (QOL) in patients with painful diabetic peripheral neuropathy (PDPN).
Twenty-six (16 males and 10 females) patients with PDPN were selected on the basis of inclusion and exclusion criteria. Subjects were randomly allocated to an experimental group ( = 13, age = 60.69 ± 5.08) and a control group (n = 13, age = 59.54 ± 4.25). The experimental group was given WBV therapy for six weeks (3 days/week) in addition to standard medical care, dietary advice and lifestyle modifications. Control group was provided only standard medical care, dietary advice and lifestyle modifications. Outcome measures included numeric pain rating scale (NPRS), Leeds assessment of neuropathic symptoms and signs (LANSS), vibration perception threshold (VPT), neuropathy disability score (NDS), proprioception, single-leg stance test (SLST), timed up and go test TUGT) and short form 36 questionnaire (SF-36).
NPRS, LANSS, NDS, SLST and TUGT showed significant time effect ( ≤ 0.022) and time×group interaction ( ≤ 0.007), whereas group effect was found to be significant only in LANSS ( = 0.001). VPT showed significant group effect ( ≤ 0.045) and time×group interaction ( ≤ 0.007) at great toe, metatarsal head and total average score. SF-36 was found to be significant time effect ( ≤ 0.024) in all domains except limitations due to physical health ( = 0.461). SF-36 average score was found be significant for group effect ( = 0.002) and time×group interaction ( < 0.001).
WBV improves sensory sensations like pain and vibration perception, neuropathy disability score, balance measures and health-related QOL in PDPN.
本研究旨在确定全身振动（WBV）疗法对疼痛性糖尿病周围神经病变（PDPN）患者的疼痛、神经病变残疾评分、平衡、本体感觉和生活质量（QOL）的疗效。
根据纳入和排除标准选取26例（16例男性和10例女性）PDPN患者。受试者被随机分为实验组（n = 13，年龄 = 60.69 ± 5.08）和对照组（n = 13，年龄 = 59.54 ± 4.25）。实验组除接受标准医疗护理、饮食建议和生活方式调整外，还接受为期六周（每周3天）的WBV治疗。对照组仅接受标准医疗护理、饮食建议和生活方式调整。结局指标包括数字疼痛评分量表（NPRS）、利兹神经病变症状和体征评估（LANSS）、振动觉阈值（VPT）、神经病变残疾评分（NDS）、本体感觉、单腿站立试验（SLST）、计时起立行走试验（TUGT）和简明健康状况调查问卷（SF - 36）。
NPRS、LANSS、NDS、SLST和TUGT显示出显著的时间效应（P ≤ 0.022）和时间×组间交互作用（P ≤ 0.007），而组间效应仅在LANSS中显著（P = 0.001）。在大脚趾、跖骨头和总平均分方面，VPT显示出显著的组间效应（P ≤ 0.045）和时间×组间交互作用（P ≤ 0.007）。SF - 36在除身体健康所致限制外的所有领域均显示出显著的时间效应（P ≤ 0.024）（P = 0.461）。SF - 36平均分显示出显著的组间效应（P = 0.002）和时间×组间交互作用（P < 0.001）。
WBV可改善PDPN患者的疼痛和振动觉等感觉、神经病变残疾评分、平衡指标以及与健康相关的生活质量。
