Ahangarpour Akram, Belali Rafie, Bineshfar Fatemeh, Javadzadeh Shokoh, Yazdanpanah Leila
Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
J Diabetes Metab Disord. 2020 Mar 7;19(1):305-309. doi: 10.1007/s40200-020-00509-0. eCollection 2020 Jun.
Nowadays, among the herbal medicines utilized to treat diabetes, (CCT) is highly noticeable as it reduces blood glucose (BG) and stimulating insulin secretion. However, long-term oral consumption of this herbal medicine has often associated with digestive complications. In this study, skin absorption of CCT as a new therapeutic approach in the treatment of type II diabetic patients has been surveyed.
40 patients with type II diabetic (aged 45-65) were selected. Participants were asked for placing their metatarsus daily in a decoction containing 2% CCT solution for 40-60 min each day and continuing that for 10 days. Blood and urine samples of patients collected at the beginning and the end of the study. The samples were examined for the BG levels, serum insulin content, lipid profiles, hepatic enzymes, urea, creatinine, and microalbuminuria, The quantitative insulin sensitivity check index (QUICKI), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β) and disposition index (DI) indicators were also calculated.
Local treatment of CCT could significantly decrease BG levels, stimulate insulin secretion and improve the function of pancreatic beta cells. It also decreased serum urea levels comparing to pre-treatment levels ( < 0.05) but there was no significant change in creatinine levels, lipid profiles, hepatic enzymes, micro-albuminuria, and other insulin sensitivity indexes.
This study demonstrated that the CCT plant can also have systemic therapeutic effects on type II diabetic patients through dermal absorption.
如今，在用于治疗糖尿病的草药中，（CCT）因其能降低血糖（BG）并刺激胰岛素分泌而备受关注。然而，长期口服这种草药常伴有消化系统并发症。在本研究中，已对CCT的皮肤吸收作为治疗II型糖尿病患者的一种新治疗方法进行了调查。
选取40例II型糖尿病患者（年龄45 - 65岁）。要求参与者每天将跖骨置于含2% CCT溶液的煎剂中40 - 60分钟，持续10天。在研究开始和结束时收集患者的血液和尿液样本。对样本进行血糖水平、血清胰岛素含量、血脂谱、肝酶、尿素、肌酐和微量白蛋白尿检测，还计算了定量胰岛素敏感性检查指数（QUICKI）、胰岛素抵抗稳态模型评估（HOMA - IR）、β细胞功能稳态模型评估（HOMA - β）和处置指数（DI）指标。
CCT的局部治疗可显著降低血糖水平，刺激胰岛素分泌并改善胰腺β细胞功能。与治疗前水平相比，血清尿素水平也有所降低（<0.05），但肌酐水平、血脂谱、肝酶、微量白蛋白尿和其他胰岛素敏感性指标无显著变化。
本研究表明，CCT植物也可通过皮肤吸收对II型糖尿病患者产生全身治疗作用。
