Soltanian Ali Reza, Hosseini Bistoon, Mahjub Hossein, Bahreini Fatemeh, Ghaffari Mohammad Ebrahim
Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Research Center for Health Sciences, School of Public Health and, Hamadan University of Medical Sciences, Hamadan, Iran.
J Diabetes Metab Disord. 2020 Apr 2;19(1):337-342. doi: 10.1007/s40200-020-00514-3. eCollection 2020 Jun.
The purpose of this study was to evaluate the association between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes in Iranian population, and also to provide a way for adjusting the deviation from the Hardy-Weinberg equilibrium.
This was a case-control study, the patients were selected from the East Azerbaijan province, Iran. In this study, 125 patients with type 2 diabetes (cases) and 125 healthy individuals (controls) were studied. Genotype and allele frequencies were determined in both groups, and the deviations from the Hardy-Weinberg equilibrium were assessed using Bayesian analysis.
A statistically significant association was observed between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes. In genotype assessing, data analysis showed that, TT genotype play a role in diabetes type 2 risk ( = 0.001). Subjects with TT genotype had a lower risk of diabetes compared to those with CC and CT genotypes. Also, there was no significant relationship between this polymorphism and type 2 diabetes mellitus in the absence of Hardy-Weinberg equilibrium.
Our findings show that, rs13266634 polymorphism was associated with the type 2 diabetes risk in the population of Eastern Azerbaijan province; however, the low number of TT homozygous genotypes affected the precision of the results. Also, the deviation from HWE affected the results. It is recommended to perform further studies to establish Hardy-Weinberg equilibrium. The inconsistency in the results may be due to the ignorance of this equilibrium.
本研究旨在评估伊朗人群中溶质载体家族30成员8（SLC30A8）基因rs13266634多态性与2型糖尿病之间的关联，并提供一种调整偏离哈迪-温伯格平衡的方法。
这是一项病例对照研究，患者选自伊朗东阿塞拜疆省。本研究对125例2型糖尿病患者（病例组）和125名健康个体（对照组）进行了研究。测定了两组的基因型和等位基因频率，并使用贝叶斯分析评估了偏离哈迪-温伯格平衡的情况。
观察到SLC30A8基因rs13266634多态性与2型糖尿病之间存在统计学显著关联。在基因型评估中，数据分析表明，TT基因型在2型糖尿病风险中起作用（P = 0.001）。与CC和CT基因型的受试者相比，TT基因型的受试者患糖尿病的风险较低。此外，在不存在哈迪-温伯格平衡的情况下，这种多态性与2型糖尿病之间没有显著关系。
我们的研究结果表明，rs13266634多态性与东阿塞拜疆省人群的2型糖尿病风险相关；然而，TT纯合基因型数量较少影响了结果的准确性。此外，偏离哈迪-温伯格平衡影响了结果。建议进行进一步研究以建立哈迪-温伯格平衡。结果的不一致可能是由于对这种平衡的忽视。
