基于金属有机框架的抗生物污损血液吸附剂用于高效去除蛋白结合胆红素
MOF-Based Antibiofouling Hemoadsorbent for Highly Efficient Removal of Protein-Bound Bilirubin.
作者信息
Li Qingsi, Guo Hongshuang, Yang Jing, Zhao Weiqiang, Zhu Yingnan, Sui Xiaojie, Xu Tong, Zhang Jiamin, Zhang Lei
机构信息
Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.
Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, China.
出版信息
Langmuir. 2020 Aug 4;36(30):8753-8763. doi: 10.1021/acs.langmuir.0c01047. Epub 2020 Jul 20.
A metal-organic framework (MOF)-based antibiofouling hemoadsorbent (PCB-MIL101) was developed through a facile encapsulation of MIL-101(Cr) in zwitterionic poly carboxybetaine (PCB) hydrogel. PCB-MIL101 possessed strong mechanical strength and superior hemocompatibility, ensuring its safety in hemoperfusion applications. In addition, it showed efficient and effective adsorption toward bilirubin (BR), and its maximum adsorption capacity was ∼583 mg g. Moreover, due to the protection of antibiofouling PCB hydrogel, PCB-MIL101 showed ability to resist protein adsorption, thus working effectively to remove BR molecules from their binding albumin in biological solutions. The finding in this study provides a novel insight into developing MOF-based hemoadsorbents for the improvement of hemoperfusion therapies.
通过将MIL-101(Cr)轻松封装在两性离子聚羧酸甜菜碱(PCB)水凝胶中，开发出了一种基于金属有机框架(MOF)的抗生物污损血液吸附剂(PCB-MIL101)。PCB-MIL101具有强大的机械强度和卓越的血液相容性，确保了其在血液灌流应用中的安全性。此外，它对胆红素(BR)表现出高效吸附，其最大吸附容量约为583 mg/g。而且，由于抗生物污损的PCB水凝胶的保护，PCB-MIL101表现出抵抗蛋白质吸附的能力，从而有效地从生物溶液中结合白蛋白的BR分子中去除BR分子。本研究中的发现为开发基于MOF的血液吸附剂以改善血液灌流疗法提供了新的见解。
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