Department of Drug Sciences, University of Pavia, Pavia, Italy.
Crit Rev Food Sci Nutr. 2021;61(15):2506-2522. doi: 10.1080/10408398.2020.1779175. Epub 2020 Jun 18.
The current literature has mainly focused on benefits and risks deriving from the consumption of caffeinated coffee and its implications for inflammation, cardiovascular diseases, neurodegenerative disorders, and cancer. Today, data about the role of caffeine in many disorders are controversial and the attention has increasingly focused on decaffeinated coffee and its non-caffeine compounds, which could have mainly beneficial effects. In fact, coffee phenolic compounds not only exhibit well-known antioxidant properties, but they can also antagonize some negative effects of caffeine, for example in inflammatory pathway and in glucose metabolism and homeostasis. In this review, we consider the literature of the last two decades and critically discuss the effects of decaffeinated coffee compounds on systemic disorders, mainly inflammation, cardiovascular diseases, hepatic dysfunctions, and cancer.
目前的文献主要集中在咖啡因摄入的益处和风险，以及其对炎症、心血管疾病、神经退行性疾病和癌症的影响。如今，关于咖啡因在许多疾病中的作用的数据存在争议，人们越来越关注脱咖啡因咖啡及其非咖啡因化合物，这些化合物可能主要具有有益的作用。事实上，咖啡中的酚类化合物不仅具有众所周知的抗氧化特性，而且还可以拮抗咖啡因的一些负面影响，例如在炎症途径以及葡萄糖代谢和稳态中。在这篇综述中，我们查阅了过去二十年的文献，并批判性地讨论了脱咖啡因咖啡化合物对全身疾病（主要是炎症、心血管疾病、肝功能障碍和癌症）的影响。
