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肠道细菌有新奇的嗜甜特性：从纤维中感知和摄取核糖。

Gut Bacteria have a novel sweet tooth: ribose sensing and scavenging from fiber.

机构信息

Department of Biosciences, School of Natural Sciences, Rice University , Houston, TX, USA.

Children's Nutrition Research Center, Baylor College of Medicine , Houston, TX, USA.

出版信息

Gut Microbes. 2020 Nov 1;11(6):1483-1485. doi: 10.1080/19490976.2020.1770667. Epub 2020 Jun 18.

DOI:10.1080/19490976.2020.1770667
PMID:32552224
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7527073/
Abstract

Dietary fiber is known to influence symbiotic gut microbiota community structure and physiology; however, how and if dietary fiber can induce further exogenous nutrient uptake within gut microbes is ill-defined. Recent findings highlight how during periods of high-fiber consumption, a prevalent gut bacteria senses and scavenges the ubiquitous sugar ribose. This molecular adaptation exemplifies how particular gut microbes have developed a sophisticated system to scavenge nutrients in a diet-dependent manner.

摘要

膳食纤维已知会影响共生肠道微生物群落结构和生理学；然而，膳食纤维如何以及是否可以在肠道微生物中诱导进一步的外源性营养吸收还不清楚。最近的研究结果强调了在高纤维摄入期间，一种普遍存在的肠道细菌如何感知和掠夺无处不在的糖核醣。这种分子适应说明了特定的肠道微生物如何以依赖饮食的方式发展出一种复杂的营养掠夺系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d64/7527073/fc8af40796cc/KGMI_A_1770667_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d64/7527073/fc8af40796cc/KGMI_A_1770667_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d64/7527073/fc8af40796cc/KGMI_A_1770667_F0001_OC.jpg

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Front Pharmacol. 2020 Mar 12;11:258. doi: 10.3389/fphar.2020.00258. eCollection 2020.
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Diet and the Human Gut Microbiome: An International Review.饮食与人类肠道微生物组：国际综述。
Dig Dis Sci. 2020 Mar;65(3):723-740. doi: 10.1007/s10620-020-06112-w.
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A Ribose-Scavenging System Confers Colonization Fitness on the Human Gut Symbiont Bacteroides thetaiotaomicron in a Diet-Specific Manner.
一种核糖清除系统以特定饮食方式赋予人类肠道共生菌拟杆菌属定植适应性。
Cell Host Microbe. 2020 Jan 8;27(1):79-92.e9. doi: 10.1016/j.chom.2019.11.009. Epub 2019 Dec 31.
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Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.短链脂肪酸（SCFAs）介导的肠道上皮和免疫调节及其对炎症性肠病的相关性。
Front Immunol. 2019 Mar 11;10:277. doi: 10.3389/fimmu.2019.00277. eCollection 2019.
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Nat Rev Gastroenterol Hepatol. 2019 Jan;16(1):35-56. doi: 10.1038/s41575-018-0061-2.
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