一种哺乳动物DNA甲基化酶的序列特异性。
The sequence specificity of a mammalian DNA methylase.
作者信息
Browne M J, Turnbull J F, McKay E L, Adams R L, Burdon R H
出版信息
Nucleic Acids Res. 1977 Apr;4(4):1039-45. doi: 10.1093/nar/4.4.1039.
Abstract
The sequence specificity of an extensively purified DNA methylase preparation from Krebs II mouse ascites cells has been examined. The enzyme appears to be highly sequence dependent. Moreover the sequence distribution of cytosine residues that are methylated, bears a very close resemblance to the sequence distribution of 5'-methyl cytosine found in vivo in a wide range of vertebrate cells and is consistent with methylation of cytosines in the sequence R-Yn-C-R.
摘要
对从克雷布斯II型小鼠腹水细胞中广泛纯化得到的DNA甲基化酶制剂的序列特异性进行了研究。该酶似乎高度依赖序列。此外，被甲基化的胞嘧啶残基的序列分布，与在多种脊椎动物细胞体内发现的5'-甲基胞嘧啶的序列分布非常相似，并且与序列R-Yn-C-R中的胞嘧啶甲基化一致。
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