Adams R L, Burdon R H, McKinnon K, Rinaldi A
FEBS Lett. 1983 Nov 14;163(2):194-8. doi: 10.1016/0014-5793(83)80817-5.
The ability of mouse Krebs II ascites cell DNA methylase to add methyl groups to native, unmethylated DNA (de novo activity) is stimulated by limited proteolysis. The affinity of the enzyme for DNA is not altered by this treatment but the rate of reaction is increased so that 40% or more of methylatable sites are methylated within 4.5 h. The activation is associated with a decrease in size of the enzyme to 6.2 S.
小鼠克雷布斯II腹水癌细胞DNA甲基化酶向天然未甲基化DNA添加甲基基团的能力（从头合成活性）受到有限蛋白酶解的刺激。这种处理不会改变该酶对DNA的亲和力，但反应速率会增加，以至于在4.5小时内40%或更多的可甲基化位点会被甲基化。这种激活与酶的大小减小至6.2 S有关。
