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1
Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation.粪便处理速度和储存时间不影响粪便微生物群移植的临床效果。
Gut Microbes. 2020 Nov 1;11(6):1806-1808. doi: 10.1080/19490976.2020.1768777. Epub 2020 Jun 18.
2
Freeze-dried fecal samples are biologically active after long-lasting storage and suited to fecal microbiota transplantation in a preclinical murine model of infection.经长期储存后，冻干粪便样本仍具有生物活性，适合用于感染的临床前小鼠模型中的粪便微生物群移植。
Gut Microbes. 2020 Sep 2;11(5):1405-1422. doi: 10.1080/19490976.2020.1759489. Epub 2020 Jun 5.
3
Recovery of the gut microbiome following fecal microbiota transplantation.粪便微生物群移植后肠道微生物群的恢复
mBio. 2014 Jun 17;5(3):e00893-14. doi: 10.1128/mBio.00893-14.
4
Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation.系统生物学评估难辨梭状芽孢杆菌感染，包括粪菌移植多次失败。
Anaerobe. 2021 Aug;70:102387. doi: 10.1016/j.anaerobe.2021.102387. Epub 2021 May 24.
5
Faecal microbiota transplantation for infection: Four years' experience of the Netherlands Donor Feces Bank.粪便微生物群移植治疗 感染：荷兰供体粪便银行四年经验。
United European Gastroenterol J. 2020 Dec;8(10):1236-1247. doi: 10.1177/2050640620957765. Epub 2020 Sep 29.
6
Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile.粪便微生物移植治疗复发性艰难梭菌感染后早期检测到的患者中重建微生物群落的定殖潜力。
BMC Microbiol. 2016 Jan 13;16:5. doi: 10.1186/s12866-015-0622-2.
7
International consensus conference on stool banking for faecal microbiota transplantation in clinical practice.国际共识会议关于粪便银行在临床实践中进行粪便微生物群移植。
Gut. 2019 Dec;68(12):2111-2121. doi: 10.1136/gutjnl-2019-319548. Epub 2019 Sep 28.
8
Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent infection and beyond: the contribution of gut microbial-derived metabolites.了解粪菌移植治疗复发性感染及其它疾病的疗效机制：肠道微生物衍生代谢物的作用。
Gut Microbes. 2020 Nov 9;12(1):1810531. doi: 10.1080/19490976.2020.1810531.
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Establishing a Fecal Microbiota Transplant Service for the Treatment of Clostridium difficile Infection.建立用于治疗艰难梭菌感染的粪便微生物群移植服务。
Clin Infect Dis. 2016 Apr 1;62(7):908-14. doi: 10.1093/cid/civ994. Epub 2015 Nov 30.
10
Transmission and clearance of potential procarcinogenic bacteria during fecal microbiota transplantation for recurrent Clostridioides difficile.复发艰难梭菌感染时粪便微生物群移植中潜在致癌菌的传播和清除。
JCI Insight. 2019 Oct 3;4(19):130848. doi: 10.1172/jci.insight.130848.

引用本文的文献

1
Impact of Fecal Microbiota Transplant Formulations, Storage Conditions, and Duration on Bacterial Viability, Functionality, and Clinical Outcomes in Patients with Recurrent Infection.粪便微生物群移植制剂、储存条件和持续时间对复发性感染患者细菌活力、功能及临床结局的影响
Microorganisms. 2025 Mar 4;13(3):587. doi: 10.3390/microorganisms13030587.
2
Modulating the microbiome in chronic liver diseases - current evidence on the role of fecal microbiota transplantation.调节慢性肝病中的微生物群——粪便微生物群移植作用的当前证据
Expert Rev Gastroenterol Hepatol. 2025 Jan;19(1):53-64. doi: 10.1080/17474124.2025.2450707. Epub 2025 Jan 16.
3
Multi-Omics Analysis Unravels the Impact of Stool Sample Logistics on Metabolites and Microbial Composition.多组学分析揭示粪便样本物流对代谢物和微生物组成的影响。
Microorganisms. 2024 Sep 30;12(10):1998. doi: 10.3390/microorganisms12101998.
4
Evaluating Bacterial Viability in Faecal Microbiota Transplantation: A Comparative Analysis of In Vitro Cultivation and Membrane Integrity Methods.评估粪便微生物群移植中的细菌活力：体外培养与膜完整性方法的比较分析。
J Clin Lab Anal. 2024 Oct;38(19-20):e25105. doi: 10.1002/jcla.25105. Epub 2024 Oct 3.
5
Developing the Common Marmoset as a Translational Geroscience Model to Study the Microbiome and Healthy Aging.将普通狨猴发展为用于研究微生物组与健康衰老的转化老年科学模型。
Microorganisms. 2024 Apr 25;12(5):852. doi: 10.3390/microorganisms12050852.
6
Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions.基于微生物组的生活方式干预分层的稳健且可推广的生物标志物的鉴定。
Microbiome. 2023 Aug 8;11(1):178. doi: 10.1186/s40168-023-01604-z.
7
Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens.抗菌药物耐药性以及近期用于控制细菌病原体（重点是食源性病原体）的抗生素替代物
Antibiotics (Basel). 2023 Jan 30;12(2):274. doi: 10.3390/antibiotics12020274.
8
Rejuvenating the human gut microbiome.焕发人类肠道微生物组活力。
Trends Mol Med. 2022 Aug;28(8):619-630. doi: 10.1016/j.molmed.2022.05.005. Epub 2022 Jun 30.
9
Stool Banking for Fecal Microbiota Transplantation: Methods and Operations at a Large Stool Bank.粪便银行用于粪便微生物群移植：大型粪便银行的方法和操作。
Front Cell Infect Microbiol. 2021 Apr 15;11:622949. doi: 10.3389/fcimb.2021.622949. eCollection 2021.

本文引用的文献

1
International consensus conference on stool banking for faecal microbiota transplantation in clinical practice.国际共识会议关于粪便银行在临床实践中进行粪便微生物群移植。
Gut. 2019 Dec;68(12):2111-2121. doi: 10.1136/gutjnl-2019-319548. Epub 2019 Sep 28.
2
The use of faecal microbiota transplant as treatment for recurrent or refractory infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines.粪便微生物群移植作为治疗复发性或难治性感染及其他潜在适应证的应用：联合英国胃肠病学会（BSG）和医疗保健感染学会（HIS）指南。
Gut. 2018 Nov;67(11):1920-1941. doi: 10.1136/gutjnl-2018-316818. Epub 2018 Aug 28.
3
Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).临床实践指南：成人和儿童艰难梭菌感染：美国传染病学会（IDSA）和美国医疗保健流行病学学会（SHEA）2017 年更新。
Clin Infect Dis. 2018 Mar 19;66(7):987-994. doi: 10.1093/cid/ciy149.
4
Profiling Living Bacteria Informs Preparation of Fecal Microbiota Transplantations.分析活细菌有助于粪便微生物群移植的准备工作。
PLoS One. 2017 Jan 26;12(1):e0170922. doi: 10.1371/journal.pone.0170922. eCollection 2017.
5
Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.冷冻与新鲜粪便微生物群移植治疗复发性艰难梭菌感染患者腹泻的临床缓解效果：一项随机临床试验。
JAMA. 2016 Jan 12;315(2):142-9. doi: 10.1001/jama.2015.18098.
6
OpenBiome remains open to serve the medical community.开放生物群落组织继续开放，为医学界提供服务。
Nat Biotechnol. 2014 Sep;32(9):867. doi: 10.1038/nbt.3006.

Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation.

作者信息

Allegretti Jessica R, Elliott Ryan J, Ladha Alim, Njenga Mary, Warren Kurt, O'Brien Kelsey, Budree Shrish, Osman Majdi, Fischer Monika, Kelly Colleen R, Kassam Zain

机构信息

Division of Gastroenterology, Brigham and Women's Hospital , Boston, MA, USA.

OpenBiome , Cambridge, MA, USA.

出版信息

Gut Microbes. 2020 Nov 1;11(6):1806-1808. doi: 10.1080/19490976.2020.1768777. Epub 2020 Jun 18.

DOI:10.1080/19490976.2020.1768777
PMID:32552337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7524162/
Abstract
摘要