Medical School of Chinese PLA, Beijing 100853, China;Department of Burn and Plastic Surgery, Burns Institute, Burn & Plastic Hospital of Chinese PLA General Hospital, Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.
Science and Technology on Transient Impact Laboratory, Beijing 102202, China.
Biomed Environ Sci. 2020 May 20;33(5):338-349. doi: 10.3967/bes2020.046.
To observe the dynamic impacts of shock waves on the severity of lung injury in rats with different injury distances.
Simulate open-field shock waves; detect the biomechanical effects of explosion sources at distances of 40, 44, and 48 cm from rats; and examine the changes in the gross anatomy of the lungs, lung wet/dry weight ratio, hemoglobin concentration, blood gas analysis, and pathology.
Biomechanical parameters such as the overpressure peak and impulse were gradually attenuated with an increase in the injury distance. The lung tissue hemorrhage, edema, oxygenation index, and pathology changed more significantly for the 40 cm group than for the 44 and 48 cm groups. The overpressure peak and impulse were significantly higher for the 40 cm group than for the 44 and 48 cm groups ( < 0.05 or < 0.01). The animal mortality was significantly higher for the 40 cm group than for the other two groups (41.2% . 17.8% and 10.0%, < 0.05). The healing time of injured lung tissues for the 40 cm group was longer than those for the 44 and 48 cm groups.
The effects of simulated open-field shock waves on the severity of lung injuries in rats were correlated with the injury distances, the peak overpressure, and the overpressure impulse.
观察冲击波对不同致伤距离大鼠肺损伤严重程度的动态影响。
模拟开阔场冲击波；检测大鼠距爆炸源 40、44 和 48 cm 处的生物力学效应；观察肺大体解剖、肺湿/干重比、血红蛋白浓度、血气分析和病理学变化。
随着致伤距离的增加，超压峰值和冲量等生物力学参数逐渐减弱。40 cm 组的肺组织出血、水肿、氧合指数和病理学改变比 44 和 48 cm 组更明显。40 cm 组的超压峰值和冲量明显高于 44 和 48 cm 组（ < 0.05 或 < 0.01）。40 cm 组的动物死亡率明显高于其他两组（41.2%. 17.8%和 10.0%， < 0.05）。40 cm 组肺组织损伤的愈合时间长于 44 和 48 cm 组。
模拟开阔场冲击波对大鼠肺损伤严重程度的影响与致伤距离、超压峰值和超压冲量有关。
