Postdoctoral Innovation Practice Base, Shenzhen Polytechnic, Shenzhen 518055, China; Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Int J Pharm. 2020 Aug 30;586:119542. doi: 10.1016/j.ijpharm.2020.119542. Epub 2020 Jun 14.
Hyaluronic acid (HA), a common biopolymer found in the extracellular fluid, was grafted with β-cyclodextrin (β-CD) to form a composite polymer that could form inclusion complexes with tocopherol (VE), enhancing its water-solubility and serving as a model drug delivery system. Herein, different copolymers were prepared with varying HA:β-CD ratios and characterized. VE loading capacity was directly correlated with increased β-CD composition in the polymers and morphological changes were observed upon VE binding. The host materials and their VE inclusion complexes are not cytotoxic, and are thus useful for VE and drug delivery.
透明质酸（HA）是一种常见的胞外液生物聚合物，它与β-环糊精（β-CD）接枝形成一种复合聚合物，可以与生育酚（VE）形成包合物，提高其水溶性，并作为药物传递系统的模型。本文用不同的 HA:β-CD 比例制备了不同的共聚物，并对其进行了表征。VE 的载药量与聚合物中β-CD 成分的增加直接相关，并且在 VE 结合时观察到形态变化。主体材料及其 VE 包合物没有细胞毒性，因此对 VE 和药物传递有用。
