School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Hai Quan Road, Shanghai 201418, PR China.
School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Hai Quan Road, Shanghai 201418, PR China.
Int J Biol Macromol. 2020 Oct 15;161:746-754. doi: 10.1016/j.ijbiomac.2020.06.088. Epub 2020 Jun 15.
Curcumin has been widely recognized as health-promoting compound. However, the intrinsic hydrophobicity, chemical instability and photodegradation limits its applications in foods. In this study, a novel emulsion was developed to encapsulate curcumin using debranched starch (DBS). The encapsulation efficiency of curcumin was 71.11% with a loading rate of 12.07%. The prepared emulsions showed better stability and solubility of curcumin than those stabilized only with Tween80 and lectin. The DBS incorporated emulsion had a uniform droplet size distribution with an average value of <1 μm. The molecular dynamics (MD) simulation showed that the water bridge between debranched starch and curcumin may play an important role in the complexation process, thus contributing to a better performance of the emulsion. This work shed light on the encapsulation process and interaction between DBS and curcumin, which is valuable to develop new emulsion-based delivery systems for bioactive lipophilic compounds using modified starch.
姜黄素已被广泛认为是一种有益健康的化合物。然而,其内在的疏水性、化学不稳定性和光降解限制了它在食品中的应用。在本研究中,开发了一种使用支链淀粉(DBS)包埋姜黄素的新型乳液。姜黄素的包封效率为 71.11%,载药量为 12.07%。与仅用 Tween80 和凝集素稳定的乳液相比,所制备的乳液显示出更好的姜黄素稳定性和溶解性。DBS 复合乳液的粒径分布均匀,平均值<1μm。分子动力学(MD)模拟表明,支链淀粉和姜黄素之间的水桥可能在络合过程中发挥重要作用,从而对乳液的性能产生积极影响。这项工作阐明了 DBS 与姜黄素的包埋过程和相互作用,这对于使用改性淀粉开发用于生物活性脂溶性化合物的新型乳液输送系统具有重要价值。