Laboratory of Materials, Macromolecules, and Composites (LaMMAC), Federal University of Technology, Apucarana 86812-460, Brazil; Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
Group of Polymers and Composite Materials (GMPC), Chemical Department, State University of Maringá (UEM), Maringá 87020-900, Brazil.
Int J Biol Macromol. 2020 Oct 15;161:977-998. doi: 10.1016/j.ijbiomac.2020.06.113. Epub 2020 Jun 15.
Conventional strategies (Turkevich's, and modified Turkevich's methods) often synthesize gold nanoparticles (AuNPs). These pathways produce AuNPs using toxic chemistries to reduce Au(III) and stabilize Au(0) atoms upon the AuNP surfaces. To overcome the disadvantages of conventional approaches, chitosan and chitosan-based materials associate with Au(III) to produce composites. Chitosan and derivatives reduce Au(III) and stabilize AuNPs, promoting biocompatibility to the composites, following approaches in-situ. In this review, we report methods to develop chitosan/AuNPs-based composites. The main criticism is about the mechanism of composite formation. Also, we highlight applications of chitosan/AuNPs-based devices in the biomedical arena. We report the synthesis of biosensors, drug delivery devices, scaffolds, antimicrobial coatings, and others. The major criticism is concerning the material design and the lack of data regarding the composite biocompatibility. We support a critical viewpoint.
常规策略（Turkevich 法和改良 Turkevich 法）常用于合成金纳米粒子（AuNPs）。这些方法使用有毒化学物质还原 Au(III)并在 AuNP 表面稳定 Au(0)原子来制备 AuNPs。为了克服传统方法的缺点，壳聚糖和壳聚糖基材料与 Au(III)结合生成复合材料。壳聚糖和衍生物还原 Au(III)并稳定 AuNPs，使复合材料具有生物相容性，这是原位方法的优势。在这篇综述中，我们报告了制备壳聚糖/AuNPs 基复合材料的方法。主要的批评是关于复合材料形成的机制。此外，我们还强调了壳聚糖/AuNPs 基器件在生物医学领域的应用。我们报告了生物传感器、药物输送装置、支架、抗菌涂层等的合成。主要的批评是关于材料设计和缺乏关于复合材料生物相容性的数据。我们支持批判性的观点。
