Yukina Marina, Nuralieva Nurana, Solovyev Maksim, Troshina Ekaterina, Vasilyev Evgeny
Department of Therapeutic Endocrinology, Endocrinology Research Centre (ERC), Moscow, Russia.
Russian Academy of Sciences, Endocrinology Service, Department of Therapeutic Endocrinology, Endocrinology Research Centre (ERC), Moscow, Russia.
Endocrinol Diabetes Metab Case Rep. 2020 Jun 4;2020. doi: 10.1530/EDM-19-0159.
Insulin autoimmune syndrome (Hirata's disease) is a disorder caused by development of autoantibodies to insulin and manifested by hypoglycaemic syndrome. The overwhelming majority of physicians do not include it in the differential diagnosis of hypoglycaemic states because of a misconception of an extremely low prevalence of this condition. This results in unnecessary drug therapy and unjustified surgical interventions in patients that otherwise would be successfully treated conservatively. This disease is strongly associated with certain alleles of the HLA gene. In most cases, this condition develops in predisposed individuals taking drugs containing sulfhydryl groups. Formation of autoantibodies to insulin may be observed in patients with other autoimmune disorders, as well as in those with multiple myeloma or monoclonal gammopathy of undetermined significance. This paper presents the first Russian case report of insulin autoimmune syndrome in an adult patient.
Insulin autoimmune syndrome, Hirata's disease, anti-insulin antibodies, and hypoglycaemia.
胰岛素自身免疫综合征（平田病）是一种由胰岛素自身抗体产生所引起的疾病，表现为低血糖综合征。绝大多数医生由于误以为这种疾病的患病率极低，因而未将其纳入低血糖状态的鉴别诊断中。这导致对原本可通过保守治疗成功治愈的患者进行了不必要的药物治疗和不合理的手术干预。这种疾病与HLA基因的某些等位基因密切相关。在大多数情况下，这种病症发生在服用含巯基药物的易感个体中。在患有其他自身免疫性疾病的患者以及患有意义未明的多发性骨髓瘤或单克隆丙种球蛋白病的患者中，也可能观察到胰岛素自身抗体的形成。本文呈现了俄罗斯首例成年患者胰岛素自身免疫综合征的病例报告。
胰岛素自身免疫综合征、平田病、抗胰岛素抗体和低血糖。
