Thaler Sebastian, Schindler Michael, Iftner Thomas, Bartz-Schmidt Karl Ulrich, Bayyoud Tarek
Department für Augenheilkunde, Eberhard Karls Universität, Elfriede-Aulhorn-Str. 7, 72076, Tübingen, Deutschland.
Institut für Medizinische Virologie und Epidemiologie, Eberhard Karls Universität, Elfriede-Aulhorn-Str. 6, 72076, Tübingen, Deutschland.
Ophthalmologe. 2020 Jul;117(7):622-625. doi: 10.1007/s00347-020-01152-z.
The appearance of the novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV‑2) poses challenges in ophthalmology particularly for eye banks. A valid risk assessment for the removal and processing of donor corneas is difficult due to the lack of data. The risk to infect transplant recipients with SARS-CoV‑2 still appears very unlikely due to the experience with severe acute respiratory syndrome -coronavirus(‑1) (SARS-CoV(‑1)) and Middle East respiratory syndrome-coronavirus (MERS-CoV); however, due to the occurrence of angiotensin-converting enzyme 2 (ACE2) receptors in the cornea an infection of this tissue with SARS-CoV‑2 cannot be completely excluded. Therefore, routine testing of the organ culture medium used for donor corneas for SARS-CoV‑2 prior to transplantation during the coronavirus disease 2019 (COVID‑19) pandemic should be considered.
新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的出现给眼科带来了挑战,尤其是对眼库而言。由于缺乏数据,对捐献角膜的摘取和处理进行有效的风险评估很困难。根据严重急性呼吸综合征冠状病毒(-1)(SARS-CoV(-1))和中东呼吸综合征冠状病毒(MERS-CoV)的经验,将SARS-CoV-2传染给移植受者的风险似乎仍然非常低;然而,由于角膜中存在血管紧张素转换酶2(ACE2)受体,不能完全排除SARS-CoV-2感染该组织的可能性。因此,在2019冠状病毒病(COVID-19)大流行期间,应考虑在移植前对用于捐献角膜的器官培养基进行SARS-CoV-2的常规检测。