Institute of Health Sciences, Lund University, SE-221 00 Lund, Sweden.
Department of Haematology, Skåne University Hospital, SE-222 45 Lund, Sweden.
Int J Environ Res Public Health. 2020 Jun 16;17(12):4302. doi: 10.3390/ijerph17124302.
Physical exercise for patients treated with allogeneic haematopoietic stem cell transplantation (allo-HSCT) has shown positive effects on the quality of life and fatigue in experimental trials. However, there is a need for longitudinal evaluation of exercise programmes implemented in a real-world clinical setting. The aim of this prospective study was to evaluate the impact of an exercise programme introduced before allo-HSCT on physical activity and fatigue before, during and after in-patient care. A structured exercise programme, including strength and endurance exercises, was implemented at a Swedish university hospital four weeks before transplantation, continuing during in-patient care and after discharge. Between March 2016 and May 2018, 67 adult patients, 33 women and 34 men with a mean age of 55.5 years participated. Fatigue was measured by the Multidimensional Fatigue Inventory at four time points. The patients documented their exercises on a checklist each week during the entire study period. The fatigue trajectory differed between various sub-groups, thus individualized supervision and support to maintain motivation is needed. In conclusion, a structured yet realistic exercise programme before admission is beneficial for allo-HSCT patients in order to reduce fatigue and prepare them for transplantation both physically and mentally.
异体造血干细胞移植（allo-HSCT）治疗患者的身体锻炼已在实验性试验中显示出对生活质量和疲劳的积极影响。然而，在真实临床环境中实施的锻炼计划需要进行纵向评估。本前瞻性研究的目的是评估在 allo-HSCT 之前引入的锻炼计划对住院期间和出院后患者身体活动和疲劳的影响。在瑞典一所大学医院，四周前开始进行包括力量和耐力训练在内的结构化锻炼计划，在住院期间和出院后继续进行。2016 年 3 月至 2018 年 5 月，共有 67 名成年患者（33 名女性和 34 名男性）参加，平均年龄为 55.5 岁。采用多维疲劳量表在四个时间点测量疲劳。患者在整个研究期间每周在检查表上记录锻炼情况。疲劳轨迹因各亚组而异，因此需要进行个性化的监督和支持以保持动力。总之，在入院前进行结构化但现实的锻炼计划对 allo-HSCT 患者有益，可减轻疲劳并使他们在身体和心理上为移植做好准备。
