Montes Raquel, Sánchez Gerard, Zhao Jingjing, Palet Cristina, Baeza Mireia, Bastos-Arrieta Julio
GENOCOV Research Group, Department of Chemical, Biological and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, Carrer de les Sitges, 08193 Bellaterra (Cerdanyola del Vallès), Spain.
GENOCOV Research Group, Department of Chemistry, Faculty of Science, Edifici C-Nord, Universitat Autònoma de Barcelona, Carrer dels Til·lers, 08193 Bellaterra (Cerdanyola del Vallès), Spain.
Nanomaterials (Basel). 2020 Jun 17;10(6):1179. doi: 10.3390/nano10061179.
The incorporation of nanomaterials on (bio)sensors based on composite materials has led to important advances in the analytical chemistry field due to the extraordinary properties that these materials offer. Nanodiamonds (NDs) are a novel type of material that has raised much attention, as they have the possibility of being produced on a large scale by relatively inexpensive synthetic methodologies. Moreover, NDs can present some other interesting features, such as fluorescence, due to surface functionalization and proved biocompatibility, which makes them suitable for biomedical applications. In addition, NDs can be customized with metallic nanoparticles (NPs), such as silver or gold, in order to combine the features of both. Raw NDs were used as modifiers of sensors due to the electrocatalytic effect of the sp and oxygenated species present on their surface. The aim of this research work is evaluating the applicability of NDs modified with silver (Ag@NDs) and gold (Au@NDs) nanoparticles for the development of a suitable (bio)sensing platform. A complete morphological and electrochemical characterization as a function of the prepared nanocomposite composition was performed in order to improve the electroanalytical properties of the developed (bio)sensors. In the present work, the optimal composition for Au@NDs present on the nanocomposite matrix is 3.5% and the one for Ag@NDs is 1%. Good results were obtained in the evaluation of the optimal composition towards hydrogen peroxide and glucose as a model analyte using a (bio)sensor based on graphite-epoxy-Ag@NDs (17:82:1).
基于复合材料的（生物）传感器中纳入纳米材料，由于这些材料具有非凡的性能，已在分析化学领域取得了重要进展。纳米金刚石（NDs）是一种新型材料，备受关注，因为它们有可能通过相对廉价的合成方法大规模生产。此外，由于表面功能化和已证实的生物相容性，NDs还可呈现出一些其他有趣的特性，如荧光，这使其适用于生物医学应用。此外，NDs可以用金属纳米颗粒（NPs）进行定制，如银或金，以便结合两者的特性。由于其表面存在的sp和含氧物种具有电催化作用，原始的NDs被用作传感器的修饰剂。本研究工作的目的是评估用银（Ag@NDs）和金（Au@NDs）纳米颗粒修饰的NDs在开发合适的（生物）传感平台方面的适用性。为了改善所开发的（生物）传感器的电分析性能，对制备的纳米复合材料组成的函数进行了完整的形态学和电化学表征。在本工作中，纳米复合基质上存在的Au@NDs的最佳组成是3.5%，Ag@NDs的最佳组成是1%。使用基于石墨 - 环氧 - Ag@NDs（17:82:1）的（生物）传感器，以过氧化氢和葡萄糖作为模型分析物对最佳组成进行评估时，获得了良好的结果。
