Department of Cardiothoracic Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province, China.
Department of Radiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang Province, China.
Surg Oncol. 2020 Jun;33:164-169. doi: 10.1016/j.suronc.2020.02.001. Epub 2020 Feb 18.
Accurate and fast localization of small pulmonary nodules is required for local pulmonary resection. In this study, we introduced and assessed a novel technique for the preoperative localization of small pulmonary nodules by using ZT medical glue (2-octyl cyanoacrylate).
101 patients who had a combined total of 106 small pulmonary nodules located by ZT glue and 53patients with 53 small pulmonary nodules located by hookwire were selected. Guided by computed tomography (CT), the surgeon injected certain volume ZT glue into an area adjacent to the small pulmonary nodule, then, the adjacent lung tissue infiltrated by ZT glue formed into a depressed hard nodule which can be used for preoperative localization with an obvious mark on lung surface or different hand touch. After localization, Wedge resection was performed via video-assisted thoracoscopic surgery and the specimen obtained from the procedure was immediately sent for pathological examination, followed by a standard surgical procedure. A contrast has been made between the ZT glue method and the hookwire.
101 operations were successfully performed by using this novel technique, and 106 small pulmonary nodules were successfully located. Compared with the hookwire location, ZT glue method obviouslyextended the Time interval between localization and operation (P = 0.00) and a same complication rate (P = 0.07).
The use of ZT glue is a safe and effective method for the localization of small pulmonary nodules.
This study was approved by the ethics committee of Shaoxing People's Hospital (Number:2016-004, Date:2016,2,24), and informed consent was obtained from all enrolled patients.
准确、快速地定位小的肺结节是进行局部肺切除的必要条件。本研究介绍并评估了一种使用 ZT 医用胶（2-辛基氰基丙烯酸酯）对小的肺结节进行术前定位的新技术。
选择了 101 例共 106 个 ZT 胶定位的小肺结节和 53 例 53 个 hookwire 定位的小肺结节的患者。在 CT 引导下，外科医生将一定体积的 ZT 胶注射到小肺结节附近的区域，然后，ZT 胶浸润的相邻肺组织形成凹陷的硬结节，可在肺表面留下明显的标记或通过不同的手感进行术前定位。定位后，通过电视辅助胸腔镜手术进行楔形切除术，从手术中获得的标本立即进行病理检查，然后进行标准的手术程序。对 ZT 胶法和 hookwire 法进行了比较。
成功地使用该新技术完成了 101 例手术，成功地定位了 106 个小的肺结节。与 hookwire 定位相比，ZT 胶定位明显延长了定位与手术之间的时间间隔（P=0.00），但并发症发生率相同（P=0.07）。
使用 ZT 胶是一种安全有效的小肺结节定位方法。
本研究得到绍兴市人民医院伦理委员会的批准（编号：2016-004，日期：2016 年 2 月 24 日），并获得所有入组患者的知情同意。
